Results 291 to 300 of about 194,605 (341)

Strategies for Small Molecule Library Design

Current Pharmaceutical Design, 2014
Compilation of an appropriate set of compounds is essential for the success of a small molecule screen. When very little is known about the target and when no or few ligands have been identified, the screening file is often made as diverse as possible. When structural information on the target or target family is available or ligands of the target are ...
Pieter F. W. Stouten, Michael J. Lipkin, David W. Sheppard, C. John Harris, Cornel Catana   +4 more
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ChemInform Abstract: Structural Diversity of Small Molecule Libraries.

ChemInform, 2001
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Jan Torleif Pedersen, Anne Marie Jørgensen   +1 more
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Library Design Practices for Success in Lead Generation With Small Molecule Libraries

Combinatorial Chemistry & High Throughput Screening, 2003
The generation of novel structures amenable to rapid and efficient lead optimization comprises an emerging strategy for success in modern drug discovery. Small molecule libraries of sufficient size and diversity to increase the chances of discovery of novel structures make the high throughput synthesis approach the method of choice for lead generation.
R. A. Goodnow, W. Haap, W. Guba
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Synthetic approaches toward small molecule libraries

2020
The drug discovery process is long and arduous, as it is estimated that the chance for a new molecule to reach the market as a rug is only 1:10,000. Thus, there is a need of a high number of small molecules, which differ not only for the appendages, but also for the molecular skeleton, to increase the chance of finding new lead compounds.
Lenci, Elena, Trabocchi, Andrea
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Small-Molecule Library Screening by Docking with PyRx

2014
Virtual molecular screening is used to dock small-molecule libraries to a macromolecule in order to find lead compounds with desired biological function. This in silico method is well known for its application in computer-aided drug design. This chapter describes how to perform small-molecule virtual screening by docking with PyRx, which is open-source
Sargis Dallakyan, Arthur J. Olson
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Carbohydrate-Derived Small-Molecule Libraries

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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ChemInform Abstract: Solution Phase Combinatorial Libraries of Small Organic Molecules

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
R. Ferritto, E. De Magistris, A. Missio, A. Paio, P. Seneci   +4 more
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Large‐Scale Annotation of Small‐Molecule Libraries Using Public Databases. [PDF]

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Frederick J. King, Yingyao Zhou, Elizabeth A. Winzeler, S. Frank Yan, Kaisheng Chen, Bin Zhou, Shumei Jiang   +6 more
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ENCODING TECHNIQUES FOR POOL LIBRARIES OF SMALL ORGANIC MOLECULES*

Journal of Receptors and Signal Transduction, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Aminomethylhydroxylation of alkenes: Exploitation in the synthesis of scaffolds for small molecule libraries

Bioorganic & Medicinal Chemistry, 2015
The application of [4+2] cycloadditions between alkenes and an N-benzoyl iminium species, generated in situ under acidic conditions, is described in the synthesis of diverse molecular scaffolds. The key reaction led to the formation of cyclic imidates in good yield and with high regioselectivity.
Colomer, Ignacio; Adeniji, Ololade; Burslem, George M.; Craven, Philip; Rasmussen, Martin Ohsten; Willaume, Anthony; Kalliokoski, Tuomo; Foster, Richard; Marsden, Stephen P.; Nelson, Adam   +10 more
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