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Strategies for the Synthesis of Glycosylated Small Molecule Libraries and New Bioactive Compounds

, 2019
Zachary Cannone
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Synthesis and Applications of Small Molecule Libraries

Chemical Reviews, 1996
One of the initial steps in the development of therapeutic agents is the identification of lead compounds that bind to the receptor or enzyme target of interest. Many analogs of these lead compounds are then synthesized to define the key recognition elements for maximal activity.
Lorin A., Thompson, Jonathan A., Ellman
semanticscholar   +4 more sources

Synthetic approaches toward small molecule libraries

2020
The drug discovery process is long and arduous, as it is estimated that the chance for a new molecule to reach the market as a rug is only 1:10,000. Thus, there is a need of a high number of small molecules, which differ not only for the appendages, but also for the molecular skeleton, to increase the chance of finding new lead compounds.
Lenci, Elena, Trabocchi, Andrea
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Peptides encode small molecule libraries

C&EN Global Enterprise, 2023
Bethany Halford
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Smart Design of Small‐Molecule Libraries: When Organic Synthesis Meets Cheminformatics

ChemBioChem, 2019
AbstractSynthetic chemists are always looking for new methods to maximize the diversity and complexity of small‐molecule libraries. Diversity‐oriented synthesis can give access to new chemotypes with high chemical diversity, exploiting complexity‐generating reactions and divergent approaches.
Lenci E., Trabocchi A.
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Design, synthesis and selection of DNA-encoded small-molecule libraries

Nature Chemical Biology, 2009
Biochemical combinatorial techniques such as phage display, RNA display and oligonucleotide aptamers have proven to be reliable methods for generation of ligands to protein targets. Adapting these techniques to small synthetic molecules has been a long-sought goal.
Matthew A, Clark, Raksha A, Acharya, Christopher C, Arico-Muendel, Svetlana L, Belyanskaya, Dennis R, Benjamin, Neil R, Carlson, Paolo A, Centrella, Cynthia H, Chiu, Steffen P, Creaser, John W, Cuozzo, Christopher P, Davie, Yun, Ding, G Joseph, Franklin, Kurt D, Franzen, Malcolm L, Gefter, Steven P, Hale, Nils J V, Hansen, David I, Israel, Jinwei, Jiang, Malcolm J, Kavarana, Michael S, Kelley, Christopher S, Kollmann, Fan, Li, Kenneth, Lind, Sibongile, Mataruse, Patricia F, Medeiros, Jeffrey A, Messer, Paul, Myers, Heather, O'Keefe, Matthew C, Oliff, Cecil E, Rise, Alexander L, Satz, Steven R, Skinner, Jennifer L, Svendsen, Lujia, Tang, Kurt, van Vloten, Richard W, Wagner, Gang, Yao, Baoguang, Zhao, Barry A, Morgan   +39 more
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Library Design Practices for Success in Lead Generation With Small Molecule Libraries

Combinatorial Chemistry & High Throughput Screening, 2003
The generation of novel structures amenable to rapid and efficient lead optimization comprises an emerging strategy for success in modern drug discovery. Small molecule libraries of sufficient size and diversity to increase the chances of discovery of novel structures make the high throughput synthesis approach the method of choice for lead generation.
R A, Goodnow, W, Guba, W, Haap
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