Results 301 to 310 of about 194,605 (341)

Discovery of a Novel Antimicrobial Agent by the Virtual Screening of a Library of Small Molecules

Molecular Informatics, 2021
AbstractA virtual screening approach based upon a combination of docking and pharmacophore methods was utilized on a library of 1.4 million molecules to identify novel antimicrobial agents, which may potentially act via inhibition of the caseinolytic protease.
Dighe, Satish N., van Akker, Suzannah R., Mathew, Marina, Perera, Madusha, Collet, Trudi A.   +4 more
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Design, Synthesis, and Evaluation of Small-Molecule Libraries

Accounts of Chemical Research, 1996
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Identification of Small Molecule Modulators of MicroRNA by Library Screening

2016
MicroRNAs (miRNAs) function as oncogenes or tumor suppressors and are dysregulated in cancer. miRNAs therefore represent promising therapeutic targets for cancer. Small molecules that could modulate the expression of miRNAs would thus have potential as anticancer agents.
Zhangang Xiao, Yangchao Chen
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Diversity Oriented Synthesis of Small Molecule Libraries

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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Cell-based high-content screening of small-molecule libraries

Current Opinion in Chemical Biology, 2007
Advanced microscopy and the corresponding image analysis have been developed in recent years into a powerful tool for studying molecular and morphological events in cells and tissues. Cell-based high-content screening (HCS) is an upcoming methodology for the investigation of cellular processes and their alteration by multiple chemical or genetic ...
Kerstin Korn, Eberhard Krausz
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Synthesis of a Library of Sulfated Small Molecules

2011
VCU Theses and ...
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Orthogonality of SFC versus HPLC for Small Molecule Library Separation

Journal of Combinatorial Chemistry, 2010
Preparative HPLC and HPLC-MS are well established as the methods of choice for purification of pharmaceutical library compounds. Recent advances in supercritical fluid chromatography (SFC) have now made SFC a viable alternative to HPLC for this application. One of the potential arguments for using SFC in place of, or in addition to, HPLC is that it may
Kurt J. Edinger, David S. Nirschl, Paul Lefebvre, Katalin Ebinger, Steven L. Hoffman, William H. Bullock, Jiang Zhao, Mark A. Hermsmeier, Harold N. Weller, Thomas Swann, Jeffrey Kiplinger   +10 more
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ChemInform Abstract: Tagged Small Molecule Library Approach for Facilitated Chemical Genetics

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ahn, Young-Hoon, Chang, Young-Tae
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yeast as a model in high throughput screening of small molecule libraries

2013
High-throughput screenings based on the use of chemical genetic approaches to Saccharomyces cerevisiae do allow for the selection of chemical compounds able to modulate a phenotype selected from the yeast model. The synthesis of large chemical libraries led to the ideation of a new approach (chemical genetics) free of the limitations associated with ...
STEFANINI, Irene, De Filippo, Carlotta, CAVALIERI, DUCCIO   +2 more
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Design, synthesis and selection of DNA-encoded small-molecule libraries

Nature Chemical Biology, 2009
Biochemical combinatorial techniques such as phage display, RNA display and oligonucleotide aptamers have proven to be reliable methods for generation of ligands to protein targets. Adapting these techniques to small synthetic molecules has been a long-sought goal.
Neil R Carlson, Alexander L. Satz, Christopher S. Kollmann, Heather O’Keefe, Matthew C Oliff, Dennis Benjamin, Yun Ding, Jinwei Jiang, Jennifer L Svendsen, Richard W. Wagner, Steffen Phillip Creaser, Christopher C. Arico-Muendel, Fan Li, Kurt D Franzen, Matthew A. Clark, Kenneth E Lind, David I. Israel, Christopher P. Davie, Kurt van Vloten, Sibongile Mataruse, Nils Jakob Vest Hansen, Raksha A. Acharya, Jeffrey A. Messer, Gang Yao, Malcolm J. Kavarana, Cynthia H. Chiu, Steven P Hale, Cecil E Rise, John W. Cuozzo, Malcolm L. Gefter, Svetlana L. Belyanskaya, Paolo A. Centrella, Lujia Tang, G Joseph Franklin, Michael Kelley, Baoguang Zhao, Barry A. Morgan, Paul Myers, Steven R. Skinner, Patricia F Medeiros   +39 more
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