Results 311 to 320 of about 194,605 (341)
Some of the next articles are maybe not open access.
Identification of CXCR3 receptor agonists in combinatorial small-molecule libraries
Biochemical and Biophysical Research Communications, 2006In a high-throughput screen of four million compounds from combinatorial libraries for small-molecule modulators of the chemokine receptor CXCR3, two classes of receptor agonists, based on tetrahydroisoquinoline and piperidinyl diazepanone templates, were identified.
Ilana L. Stroke +9 more
openaire +2 more sources
PNA-Encoded Synthesis (PES) and DNA Display of Small Molecule Libraries
2020DNA-encoded library technologies have emerged as a powerful platform to rapidly screen for binders to a protein of interest. These technologies are underpinned by the ability to encode a rich diversity of small molecules. While large libraries are accessible by cycles of mix and split synthesis, libraries based on single chemistries tend to be ...
Saarbach, Jacques +2 more
openaire +3 more sources
ChemInform Abstract: Direct Deconvolution Techniques for Pool Libraries of Small Organic Molecules
ChemInform, 2000AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
openaire +5 more sources
Journal of Combinatorial Chemistry, 2008
In "one-bead-one-compound" (OBOC) combinatorial chemistry, a compound-bead library with hundreds of thousands to millions of diversities can be rapidly generated such that each bead displays only one chemical entity. The highly efficient "libraries-from-libraries" approach involves the global transformation of a peptide library into many small molecule
Kit S. Lam, Joseph C. Kappel, Yi C. Fan
openaire +3 more sources
In "one-bead-one-compound" (OBOC) combinatorial chemistry, a compound-bead library with hundreds of thousands to millions of diversities can be rapidly generated such that each bead displays only one chemical entity. The highly efficient "libraries-from-libraries" approach involves the global transformation of a peptide library into many small molecule
Kit S. Lam, Joseph C. Kappel, Yi C. Fan
openaire +3 more sources
Journal of Combinatorial Chemistry, 2008
We present a method to automatically plan a robotic process to mix individual combinations of reactants in individual reaction vessels (vials or wells in a multiwell plate), mixing any number of reactants in any desired stoichiometry, and ordering the mixing steps according to an arbitrarily complex treelike assembly protocol.
Shelley Weaver +4 more
openaire +3 more sources
We present a method to automatically plan a robotic process to mix individual combinations of reactants in individual reaction vessels (vials or wells in a multiwell plate), mixing any number of reactants in any desired stoichiometry, and ordering the mixing steps according to an arbitrarily complex treelike assembly protocol.
Shelley Weaver +4 more
openaire +3 more sources
Combinatorial Synthesis of a Small-Molecule Library Based on the Vinyl Sulfone Scaffold
Organic Letters, 2003[reaction: see text] A 30-member library of small molecules based on the vinyl sulfone scaffold was prepared on rink amide resin, using solid phase-based reactions such as oxidation and Horner-Wadsworth-Emmons reaction. The library was designed such that three points of diversity were readily introduced in the library to accommodate the S(1)', S(1 ...
Wang, G., Yao, S.Q.
openaire +3 more sources
Novel Strategies for Solid‐Phase Construction of Small Molecule Combinatorial Libraries
ChemInform, 2001During the past decade we witnessed a rapid advance in the new field of chemical science, combinatorial chemistry. The pharmaceutical industries invested heavily in accelerating the development of this new technology. As a result, it has become an extremely important tool in lead identification and optimization in current pharmaceutical research.
openaire +4 more sources
BAGS: An automated Barcode, Audit & Grade System for DNA barcode reference libraries
Molecular Ecology Resources, 2021João T Fontes +2 more
exaly
Synthon-based ligand discovery in virtual libraries of over 11 billion compounds
Nature, 2022Arman Sadybekov +2 more
exaly