Results 51 to 60 of about 645,880 (357)

Identification of Small Molecule Inhibitors of Clostridium perfringens ε-Toxin Cytotoxicity Using a Cell-Based High-Throughput Screen

Toxins, 2010
The Clostridium perfringens epsilon toxin, a select agent, is responsible for a severe, often fatal enterotoxemia characterized by edema in the heart, lungs, kidney, and brain. The toxin is believed to be an oligomeric pore-forming toxin.
Mark S. McClain, Michelle Lewis, Charles David Weaver   +2 more
doaj   +1 more source

Identification of Inhibitors of Integrin Cytoplasmic Domain Interactions With Syk

Frontiers in Immunology, 2021
Leukocyte inflammatory responses require integrin cell-adhesion molecule signaling through spleen tyrosine kinase (Syk), a non-receptor kinase that binds directly to integrin β-chain cytoplasmic domains.
Deenadayalan Bakthavatsalam, John W. Craft, John W. Craft, Anna Kazansky, Nghi Nguyen, Goeun Bae, Amy R. Caivano, C. William Gundlach, Asra Aslam, Safa Ali, Shashikant Gupta, Sophie Y. Lin, Hema D. Parthiban, Peter Vanderslice, Clifford C. Stephan, Darren G. Woodside   +15 more
doaj   +1 more source

Inductive queries for a drug designing robot scientist [PDF]

, 2010
It is increasingly clear that machine learning algorithms need to be integrated in an iterative scientific discovery loop, in which data is queried repeatedly by means of inductive queries and where the computer provides guidance to the experiments that ...
A. Lingas, C. Hansch, C.A. Lipinski, D.R. Jones, D.R. Jones, H. Blockeel, J. Matousek, L. Raedt De, R.D. King, R.D. King, T. Gärtner   +10 more
core   +1 more source

Expression proteomics reveals protein targets and highlights mechanisms of action of small molecule drugs

, 2014
Phenomenological screening of small molecule libraries for anticancer activity yields potentially interesting candidate molecules, with a bottleneck in the determination of drug targets and the mechanism of anticancer action.
Chernobrovkin, Alexey, Vicente, Consuelo Marin, Visa, Neus, Zubarev, Roman A.   +3 more
core   +1 more source

Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. [PDF]

, 2011
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) emerged as the causal agent of an endemic atypical pneumonia, infecting thousands of people worldwide.
Agudelo, Juliet, Amberg, Sean M, Chen, Yen Ting, Craik, Charles S, Goetz, David H, Hansell, Elizabeth, Lu, Kai, McKerrow, James, Roush, William R, Simmons, Graham, Zhou, Yanchen   +10 more
core   +1 more source

Synthetic biology: advancing biological frontiers by building synthetic systems [PDF]

, 2012
Advances in synthetic biology are contributing to diverse research areas, from basic biology to biomanufacturing and disease therapy.
Chen, Yvonne Y., Galloway, Kate E., Smolke, Christina D.   +2 more
core   +5 more sources

Recent advances in the discovery and design of multicomponent reactions for the generation of small-molecule libraries

, 2015
: The current drug discovery process is dependent on the ability of synthetic chemistry to deliver libraries of small molecules with ever increasing levels of structural complexity and diversity.
H. Malinakova
semanticscholar   +1 more source

Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. [PDF]

, 2016
We identified drug seeds for treating Huntington's disease (HD) by combining in vitro single molecule fluorescence spectroscopy, in silico molecular docking simulations, and in vivo fly and mouse HD models to screen for inhibitors of abnormal ...
Chen, Xigui, Finkbeiner, Steven, Fujita, Kyota, Homma, Hidenori, Ikura, Teikichi, Imamura, Tomomi, Ito, Nobutoshi, Kaye, Julia, Mao, Ying, Motoki, Kazumi, Nakabayashi, Makoto, Okano, Hideyuki, Okazawa, Hitoshi, Tagawa, Kazuhiko, Tamura, Takuya, Taniguchi, Juliana Bosso, Tomii, Kentaro, Yamada, Kazunori   +17 more
core   +2 more sources

Identification of protein interaction antagonists using the repressed transactivator two-hybrid system

BioTechniques, 2007
The repressed transactivator (RTA) yeast two-hybrid system was developed to enable genetic identification of interactions with transcriptional activator proteins.
Phalgun B. Joshi, Martin Hirst, Tom Malcolm, Jennifer Parent, David Mitchell, Karen Lund, Ivan Sadowski   +6 more
doaj   +1 more source

Software Tools and Approaches for Compound Identification of LC-MS/MS Data in Metabolomics. [PDF]

, 2018
The annotation of small molecules remains a major challenge in untargeted mass spectrometry-based metabolomics. We here critically discuss structured elucidation approaches and software that are designed to help during the annotation of unknown compounds.
Blaženović, Ivana, Fiehn, Oliver, Ji, Jian, Kind, Tobias   +3 more
core   +3 more sources