Results 61 to 70 of about 194,605 (341)

A simple method to identify kinases that regulate embryonic stem cell pluripotency by high-throughput inhibitor screening [PDF]

, 2017
Embryonic stem cells (ESCs) can self-renew or differentiate into all cell types, a phenomenon known as pluripotency. Distinct pluripotent states have been described, termed "naïve" and "primed" pluripotency.
Findlay, Greg M., Gray, Nathanael S., Williams, Charles A. C.   +2 more
core   +3 more sources

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

High-throughput Identification of Phage-derived Imaging Agents

Molecular Imaging, 2006
The use of phage-displayed peptide libraries is a powerful method for selecting peptides with desired binding properties. However, the validation and prioritization of “hits” obtained from this screening approach remains challenging.
Kimberly A. Kelly, Paul A. Clemons, Amy M. Yu, Ralph Weissleder   +3 more
doaj   +1 more source

Novel allosteric sites on Ras for lead generation. [PDF]

PLoS ONE, 2011
Aberrant Ras activity is a hallmark of diverse cancers and developmental diseases. Unfortunately, conventional efforts to develop effective small molecule Ras inhibitors have met with limited success.
Barry J Grant, Suryani Lukman, Harrison J Hocker, Jaqueline Sayyah, Joan Heller Brown, J Andrew McCammon, Alemayehu A Gorfe   +6 more
doaj   +1 more source

Combination of small molecule microarray and confocal microscopy techniques for live cell staining fluorescent dye discovery [PDF]

, 2013
Discovering new fluorochromes is significantly advanced by high-throughput screening (HTS) methods. In the present study a combination of small molecule microarray (SMM) prescreening and confocal laser scanning microscopy (CLSM) was developed in order to
Bokros, Attila, Cingaram, Pradeep Kumar Reddy, Fábián, Gabriella, Kuntam, Soujanya, Molnár, Eszter, Peksel, Begüm, Puskás, László G.   +6 more
core   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Synthesis of novel piperazine-linked anthranilic acids as potential small molecule kinase inhibitors [PDF]

, 2013
Please cite as follows: Chakravorty, S. et al. 2014. Synthesis of novel piperazine-linked anthranilic acids as potential small molecule kinase inhibitors.
Chakravorty, Santanu, Fang, Zhizhou, Hodson, Luke E., Klein, Hanna F., Pelly, Stephen C., Rabillier, Matthias, Rauh, Daniel, Richters, Andre, Van Otterlo, Willem A. L.   +8 more
core  

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Identification of a novel retinoid by small molecule screening with zebrafish embryos. [PDF]

PLoS ONE, 2008
Small molecules have played an important role in delineating molecular pathways involved in embryonic development and disease pathology. The need for novel small molecule modulators of biological processes has driven a number of targeted screens on large
Chetana Sachidanandan, Jing-Ruey J Yeh, Quinn P Peterson, Randall T Peterson   +3 more
doaj   +1 more source

Xenopus: An ideal system for chemical genetics [PDF]

, 2012
Chemical genetics, or chemical biology, has become an increasingly powerful method for studying biological processes. The main objective of chemical genetics is the identification and use of small molecules that act directly on proteins, allowing rapid ...
Adams, Adams, Almogy, Banaszynski, Blackiston, Blackiston, Brändli, Cambridge, Carneiro, Chae, Chang, Chen, Clark, Dale, Das, Davidson, Deiters, Dodd, Dupre, Dush, Fini, Frank-Kamenetsky, Fukumoto, Garcia-Morales, Goda, Grammer, Hanvey, Hartley, Heasman, Horb, Huang, Kalin, Kolm, Lennox, Levin, Liu, Liu, Liu, Longo, Love, Lund, Meijer, Morckel, Nielsen, Nusslein-Volhard, Obika, Paddison, Page-McCaw, Peterson, Peterson, Pownall, Rankin, Reya, Richards, Rones, Schneider, Shestopalov, Stankunas, Tomlinson, Tomlinson, Tomlinson, Tomlinson, Tomlinson, Van Raay, Vandenberg, Verma, Wahlestedt, Walsh, Wheeler, Wheeler, White, Wignall, Woolf, Yang   +73 more
core   +1 more source