Results 111 to 120 of about 1,485,416 (350)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

ELNet: An Efficient and Lightweight Network for Small Object Detection in UAV Imagery

Remote Sensing
Real-time object detection is critical for unmanned aerial vehicles (UAVs) performing various tasks. However, efficiently deploying detection models on UAV platforms with limited storage and computational resources remains a significant challenge.
Hui Li, Jianbo Ma, Jianlin Zhang
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A Small-Object-Detection Algorithm Based on LiDAR Point-Cloud Clustering for Autonomous Vehicles. [PDF]

Sensors (Basel)
3D object-detection based on LiDAR point clouds can help driverless vehicles detect obstacles. However, the existing point-cloud-based object-detection methods are generally ineffective in detecting small objects such as pedestrians and cyclists ...
Duan Z, Shao J, Zhang M, Zhang J, Zhai Z.   +4 more
europepmc   +2 more sources

A Small-Object Detection Model Based on Improved YOLOv8s for UAV Image Scenarios

Remote Sensing
Small object detection for unmanned aerial vehicle (UAV) image scenarios is a challenging task in the computer vision field. Some problems should be further studied, such as the dense small objects and background noise in high-altitude aerial photography
J. Ni, Shengjie Zhu, Guangyi Tang, Chunyan Ke, Tingting Wang   +4 more
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

MCF-YOLOv5: A Small Target Detection Algorithm Based on Multi-Scale Feature Fusion Improved YOLOv5

Information
In recent years, many deep learning-based object detection methods have performed well in various applications, especially in large-scale object detection.
Song Gao, Mingwang Gao, Zhihui Wei
doaj   +1 more source