Results 31 to 40 of about 114,793 (255)

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Impact of Wheel-rail Lubrication on Outer Rail Wear in Metro Small Radius Curved Segments

Chengshi guidao jiaotong yanjiu
[Objective] For metro lines with high proportion of small radius curved segments and severe rail wear, lubrication can alter wheel-rail contact area friction coefficient and in turn effectively reduce rail wear, thus it is necessary to study the ...
Xinwei LUO, Bin ZHANG, Longyang WANG, Qingsong FENG   +3 more
doaj   +1 more source

Research on Construction Technology for Shield Tunnelling with Small Curve Radius under Shallow Cover Conditions [PDF]

E3S Web of Conferences
This article takes the shield tunnelling project of the southern entrance of Line 7 of Changsha Metro as a practical background, focusing on extremely complex working conditions including shallow cover (with a minimum thickness of only 3.8m, equivalent ...
Niu Ben, Huang Lihui, Jia Jianwei, Liu Ying, Zhang Zexin, Jiang Yanxiang, Song Hongying   +6 more
doaj   +1 more source

Study on the Horizontal Axis Deviation of a Small Radius TBM Tunnel Based on Winkler Foundation Model

Applied Sciences, 2020
During the construction stage of the small radius TBM (tunnel boring machine) interval, the improper control of the boring parameters and the boring posture can cause the horizontal axis deviation of the shield tunnel. In order to address this issue, the
Shifan Qiao, Ping Xu, Ritong Liu, Gang Wang   +3 more
doaj   +1 more source

Revisiting Stability Criteria in Ball‐Milled High‐Entropy Alloys: Do Hume–Rothery and Thermodynamic Rules Equally Apply?

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
The stability criteria affecting the formation of high‐entropy alloys, particularly focusing in supersaturated solid solutions produced by mechanical alloying, are analyzed. Criteria based on Hume–Rothery rules are distinguished from those derived from thermodynamic relations. The formers are generally applicable to mechanically alloyed samples.
Javier S. Blázquez, Alejandro F. Manchón‐Gordón, Antonio Vidal‐Crespo, Rafael Caballero‐Flores, Jhon J. Ipus, Clara F. Conde   +5 more
wiley   +1 more source

Stator Curvature Optimization and Analysis of Axial Hydraulic Vane Pumps

Energies, 2022
Aiming at the problem of large vibration of a high-subside stator inner cavity curve vane pump, the force analysis of the vane at the transition curve is carried out, and the functional relationship between the vane turning angle θ, the large arc radius ...
Yongguo Sun, Dong Xue, Shisheng Liu, Jinghang Wu, Xingyu Bai   +4 more
doaj   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

Analysis on the Causes of Cracks in Curved Box Girder Bridges with Small Radius

IOP Conference Series: Earth and Environmental Science, 2020
Abstract At present, curved box girder bridges with small radius is widely used in modern highway and urban road interchange flyover, especially in the design of ramp bridge of interchange flyover. Taking the ramp of Liaoyang Road to Haier Road Flyover in Laoshan District of Qingdao as an example, this paper calculates and compares the ...
Shuqing Zhao, Guofeng Li
openaire   +1 more source

Research on a Trackside Concrete Reinforcement Scheme of a Small Radius Curve at a Junction Section of a Modern Tram

Slovak Journal of Civil Engineering, 2021
In order to ensure the normal use of a junction section of a modern tram, this paper mainly studied a trackside concrete reinforcement scheme. Firstly, the entire non-reinforcement system model with a small radius curve composed of rail, fastener ...
Wang Zhiqiang, Lei Zhenyu
doaj   +1 more source