Results 121 to 130 of about 5,862,706 (262)

Annotation and distribution of small RNAs among different categories.

, 2013
(A) Pie chart for annotation of unique tags of small RNAs in HepG2; (B) Pie chart for annotation of total tags of small RNAs in HepG2; (C) Pie chart for annotation of unique tags of small RNAs in HepG2/DOX; (D) Pie chart for annotation of total tags of ...
Yanxin Lu (276664), Wei Zhang (405), Jun Wan (126294), Lin Zhou (141050), Ying Wang (11406), Pingping Zhen (276663), Chao Zhang (51048), Yang Yang (45629), Jufeng Zhang (276662), Xia Luo (169127)   +9 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

siRNAs, tRNAs, and rRNAs in Osteoarthritis: Biological Functions and Therapeutic Opportunities

Biologics: Targets & Therapy
Mina Wang,1,* Yidan Dai,1,* Xiaobo Ge,1,* Libin Zheng,1,2 Miaoxin Zhai,3 Wenshan Li,1,2 Guannan Liu,1 Xiaoyu Cheng,1 Jiangyan Wei,1 Xin Yang,1 Lu Liu,1 Huilin Liu,1 Jingqing Sun,1 Bin Li,1 Fang Yuan1 1Department of Acupuncture and
Wang M, Dai Y, Ge X, Zheng L, Zhai M, Li W, Liu G, Cheng X, Wei J, Yang X, Liu L, Liu H, Sun J, Li B, Yuan F   +14 more
doaj  

Characterization of viral small RNAs.

, 2016
(A-G): Analysis of viral small RNAs from the Controls and RNA silencing mutant strains. Significant differences between the Control and RNA silencing mutant strains are indicated where “a”: p A) Summary of genomic loci that produce small RNAs as a ...
James C. Carrington (6121), Kerrigan B. Gilbert (474711), Sonia Campo (755808)   +2 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Small regulatory RNAs in mammals

, 2005
Mammalian cells harbor numerous small non-protein-coding RNAs, including small nucleolar RNAs (snoRNAs), microRNAs (miRNAs), short interfering RNAs (siRNAs) and small double-stranded RNAs, which regulate gene expression at many levels including chromatin
John S. Mattick, Igor V. Makunin, Mattick, J. S., Makunin, I. V.   +3 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Microarray analysis of small non-coding RNAs.

, 2015
Microarray technology has evolved to efficiently profile the expression of RNAs. However, analysis of small non-coding RNAs (ncRNAs) is challenging due to their short length and highly divergent sequences with large variation in GC content leading to ...
Scheideler, M., Karbiener, M.
core   +1 more source