Results 231 to 240 of about 5,862,706 (262)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

The Liver Fluke <i>Opisthorchis felineus</i> Exosomal tRNA-Derived Small RNAs as Potential Mediators of Host Manipulation. [PDF]

Biomolecules
Lishai E, Pakharukova M.
europepmc   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Identification and analysis of small RNAs in exosome-like nanoparticles derived from onion (<i>Allium cepa L.</i>). [PDF]

Biochem Biophys Rep
Liang Z, Gu Y, Song J, Yang W, Xu X.
europepmc   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Delving into tRNA-derived small RNAs in multiple myeloma: elevated 3'U-tRF^SerTGA leads to poor disease prognosis. [PDF]

Br J Cancer
Soureas K, Malandrakis P, Papadimitriou MA, Ntanasis-Stathopoulos I, Pilala KM, Liacos CI, Gavriatopoulou M, Kastritis E, Dimopoulos MA, Scorilas A, Terpos E, Avgeris M.   +11 more
europepmc   +1 more source

Hfq-dependent artificial regulatory small RNAs for targeted gene expression control in the nitrogen-fixing <i>Pseudomonas stutzeri</i> A1501. [PDF]

Synth Syst Biotechnol
Han Y, Zhang Y, Li C, Lin M, Lv F, Qi C, Yan Y, Zhan Y.   +7 more
europepmc   +1 more source

Extracellular Small RNAs in Human Milk: Molecular Profiles, Stability and Fragment-Specific Responses in Cell-Based Assays. [PDF]

Noncoding RNA
Claus C, Borini Etichetti C, Costa B, Grosso JB, Tosar JP, Chorostecki U, Spinelli SV.   +6 more
europepmc   +1 more source

Bacterial Regulatory Circuits are Linked and Extended by Small RNAs. [PDF]

J Mol Biol
Gottesman S.
europepmc   +1 more source

Emerging roles and therapeutic potential of tRNA-Derived small RNAs in reproductive system diseases: a review. [PDF]

Front Cell Dev Biol
Zhou Q, He M, Liu M, Sun G, Li J.
europepmc   +1 more source