Results 81 to 90 of about 15,601,125 (299)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Loss functions, utility functions and Bayesian sample size determination. [PDF]
, 2011 PhDThis thesis consists of two parts. The purpose of the first part of the research is to obtain Bayesian sample size determination (SSD) using loss or utility function with a linear cost function. A number of researchers have studied the Bayesian SSD
Islam, A. F. M. Saiful
core +2 more sources
Use of Bayesian approaches in oncology clinical trials: A cross-sectional analysis
Frontiers in PharmacologyPurposeBayesian approaches may improve the efficiency of trials and accelerate decision-making, but reluctance to depart from traditional frequentist statistics may limit their use.
Borja G. Lopez-Rey +9 more
doaj +1 more source
Structural Equation Modeling With Many Variables: A Systematic Review of Issues and Developments
Frontiers in Psychology, 2018 Survey data in social, behavioral, and health sciences often contain many variables (p). Structural equation modeling (SEM) is commonly used to analyze such data.
Lifang Deng +2 more
doaj +1 more source
Nonparametric Independence Testing for Small Sample Sizes
, 2014 This paper deals with the problem of nonparametric independence testing, a fundamental decision-theoretic problem that asks if two arbitrary (possibly multivariate) random variables $X,Y$ are independent or not, a question that comes up in many fields like causality and neuroscience. While quantities like correlation of $X,Y$ only test for (univariate)
Aaditya Ramdas, Leila Wehbe
openaire +3 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Baozha yu ChongjiTo address the challenges posed by insufficient statistical sampling density and inherent irreducible uncertainties in multi-physical property detonation experiments, probability learning on manifold (PLoM) involving diffusion map and Itô projection ...
Xiao LIANG, Yanfei ZHAO, Ruili WANG
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The Post-entry Size Adjustment of New small Firms [PDF]
The hypothesis underlined in this paper is that apart from infant mortality there is another relevant phenomenon taking place within new-born Small Business Enterprises (SBEs) in the period immediately after entry; namely that the smaller ones among them,
Enrico Santarelli +2 more
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