Results 31 to 40 of about 6,897 (216)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A Single Motor-Driven Focusing Mechanism with Flexure Hinges for Small Satellite Optical Systems

Applied Sciences, 2020
For earth observation, the optical systems in small satellites are crucial to obtain high- resolution images. However, the alignment between a primary and a secondary mirror in an optical system can be disturbed due to the harsh environments inside ...
Jinwon Jung, Nguyen Van Sy, Dongkyu Lee, Seonggun Joe, Jaihyuk Hwang, Byungkyu Kim   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Spaceborne SAR System Design Considerations: Minimizing Satellite Size and Mass, System Parameter Trade-Offs, and Optimization

Applied Sciences
The goal of this research is to assess and guide the development of next-generation synthetic aperture radar (SAR) satellites, optimize their performance, and present the requirements related to the design parameters. In the current era, characterized by
Ersin Makas, Alim Rüstem Aslan
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Convolutional Autoencoders for Data Compression and Anomaly Detection in Small Satellite Technologies

Information
Small satellite technologies have enhanced the potential and feasibility of geodesic missions through the simplification of design and decreased costs allowing for more frequent launches.
Dishanand Jayeprokash, Julia Gonski
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Small-Satellite System Fault Diagnosis via a Temporal–Spatial 3D-CNN with Imbalanced-Aware Training

Sensors
Reliable onboard fault detection and diagnosis (FDD) is essential for autonomous small-satellite constellation operations. The satellite telemetry streams are typically high-dimensional, strongly time-correlated, and severely imbalanced.
Bin Wang, Shu Ting Goh, Sheral Crescent Tissera, Abhishek Rai, Lijie Zhang   +4 more
doaj   +1 more source

TCR Antenna For Small Satellite Application

Algerian Journal of Signals and Systems, 2018
The results of this study are interesting about antenna technology generation used in small satellite. A new design optimized of the TCR (tracking, command and ranging) antenna has been presented.
Z. KOURDI, O. KARA ALI
doaj   +1 more source