Results 41 to 50 of about 6,897 (216)

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

NUMERICAL INVESTIGATION ON THE THERMOMECHANICAL PERFORMANCES OF NANOSATELLITE ASSEMBLIES [PDF]

Annals of the University of Petroşani. Mechanical Engineering
The present paper proposes a new approach for the thermomechanical analysis of small satellites. In the first stage, the heat fluxes acting on the exterior surfaces of the assembly are evaluated with the support of the CubeSat Wizard.
TUDOR GEORGE ALEXANDRU, FLOREA DOREL ANANIA, CRISTINA PUPAZA, COSMIN GOGU   +3 more
doaj  

A Satellite-USV System for Persistent Observation of Mesoscale Oceanographic Phenomena

Remote Sensing, 2021
Traditional tools and methodologies for mesoscale observation of oceanographic phenomena are limited by under-sampling and data latency. In this article we evaluate three different scenario variants of an architecture for how heterogeneous sensor nodes ...
Alberto Dallolio, Gara Quintana-Diaz, Evelyn Honoré-Livermore, Joseph L. Garrett, Roger Birkeland, Tor A. Johansen   +5 more
doaj   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Integrating Time‐Adjusted Imaging Instability Into Functional Outcome Prediction After Intracerebral Hemorrhage: Development and Validation of the HAGIV Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early risk stratification may support clinical decision‐making in spontaneous intracerebral hemorrhage (ICH). We aimed to develop and internally validate HAGIV, a score integrating frequency of imaging markers (FIM), a time‐adjusted non‐contrast computed tomography (CT) metric of hematoma expansion, with established predictors for 90‐
Lei Song, Ren Ke, Anqi Chen, Yufei Fu, Hang Zhou, Rujia Wang, Liwei Zou, Yongqiang Yu, Ming Yuan, Xiaoming Qiu, Mengzhou Xue   +10 more
wiley   +1 more source

Preliminary Design of Satellite Systems through the Integration of Model-Based System Engineering and Agile Methodologies: Application to the ³ColStar Mission

Aerospace
This paper presents a case study on integrating Agile Systems Engineering methodologies in the preliminary design phase of satellite systems, focusing on the 3ColStar satellite mission.
Jeimmy Nataly Buitrago-Leiva, Juan José Mejía, Juan Francisco Puerta-Ibarra, Ignacio Francisco Acero-Niño, Andrés Felipe Guarnizo-Saavedra, Julian Rodriguez-Ferreira, Leandro Rojas-Rodriguez, Francisco Luis Hernández-Torres, Cristian Esteban Arango-Cotacio, Jorge Enrique Salazar-Morales, Miguel Angel Herrera-Cruz, Mario Linares-Vásquez, Jose Fernando Jiménez-Vargas, Jorge Enríque Espíndola-Díaz, Óscar Javier Montañez-Sogamoso, Adriano Camps   +15 more
doaj   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

A Deployable Conical Log Spiral Antenna for Small Spacecraft: Mechanical Design and Test

Aerospace
We present the design and manufacturing of a deployable conical log spiral spring antenna for small spacecraft, along with a test campaign to evaluate its suitability for space applications.
Lewis R. Williams, Natanael Hjermann, Bendik Sagsveen, Arthur Romeijer, Karina Vieira Hoel, Lars Erling Bråten   +5 more
doaj   +1 more source

“Low‐Positive” MOG‐IgG Cases Among Adults With a First Event Suggestive of Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the prevalence and clinical characteristics of patients with “low‐positive” (LP) MOG‐IgG (titres 1:160–1:320) among adults with a first demyelinating event (FDE) suggestive of multiple sclerosis (MS). Methods From the Barcelona CIS inception cohort, we included adult patients with serum collected ≤ 6 months from the FDE.
Javier Villacieros‐Álvarez, Carmen Espejo, Georgina Arrambide, Mireia Castillo, Marta Rodriguez, Helena Ariño, Iker Elosua, Carmen Tur, Angela Vidal‐Jordana, Andreu Vilaseca, Joaquín Castilló, Ingrid Galán, Luciana Midaglia, Carlos Nos, Breogan Rodríguez‐Acevedo, Ana Zabalza, Luca Bollo, Agustín Pappolla, René Carvajal, Neus Mongay‐Ochoa, Jordi Rio, Jaume Sastre‐Garriga, Manuel Comabella, Gesualdina Busiello, Sofia Sceppacuercia, Àlex Rovira, Xavier Montalban, Mar Tintoré, Cristina Auger, Álvaro Cobo‐Calvo   +29 more
wiley   +1 more source

Wire-Based Solid-State Propellant Management System for Small Form-Factor Space Propulsion

Inventions
The development of dynamic missions of small satellites requires the development of efficient, compact, and reliable propulsion systems (PSs). This paper investigates a propellant storage and supply system (PSSS), utilizing alternative solid-state ...
Pavel O. Savelev, Andrei I. Shumeiko, Victor D. Telekh   +2 more
doaj   +1 more source