Results 81 to 90 of about 7,912,278 (276)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Bounding surface constitutive model for soft soils considering characteristics of small-strain stiffness and its application in engineering

Yantu gongcheng xuebao
The construction of an excavation pit induces complex loading-unloading stress paths in the surrounding soils, while the commonly used constitutive models are insufficient to reflect the over-consolidation and small-strain stiffness characteristics ...
LIANG Fayun 1, ZHENG Hanbo 1, LI Lin 2, WANG Rulu 3, YAN Jingya 3
doaj   +1 more source

Quantitative two-dimensional strain mapping of small core–shell FePt@Fe3O4 nanoparticles

New Journal of Physics, 2016
We report a facile one-pot chemical synthesis of colloidal FePt@Fe _3 O _4 core–shell nanoparticles (NPs) with an average diameter of 8.7 ± 0.4 nm and determine their compositional morphology, microstructure, two-dimensional strain, and magnetic ...
Marianne Monteforte, Shoko Kobayashi, Le D Tung, Koichi Higashimine, Derrick M Mott, Shinya Maenosono, Nguyen T K Thanh, Ian K Robinson   +7 more
doaj   +1 more source

Heterogeneity of the Abnormal Prion Protein (PrPSc) of the Chandler Scrapie Strain

Pathogens, 2013
The pathological prion protein, PrPSc, displays various sizes of aggregates. In this study, we investigated the conformation, aggregation stability and proteinase K (PK)-sensitivity of small and large PrPSc aggregates of mouse-adapted prion strains.
Takashi Yokoyama, Shirou Mohri, Morikazu Imamura, Yoshifumi Iwamaru, Kentaro Masujin, Kazuo Kasai   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Assessment of small strain modulus in soil using advanced computational models. [PDF]

Sci Rep, 2023
Fan H, Hang T, Song Y, Liang K, Zhu S, Fan L.   +5 more
europepmc   +1 more source

The Small Strain Stiffness of a Carbonate Stiff Clay

Soils and Foundations, 1995
ABSTRACT Knowledge of the small strain stiffness of the heavily overconsolidated Gault Clay, which has up to 30% calcium carbonate content, is rather limited. This has resulted in some difficulties in the analysis and design of structures constructed in the Gault.
Ng, Charles Wang Wai CIVL, Bolton, Malcolm D., Dasari, Ganeswara Rao   +2 more
openaire   +3 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Coupled Effect of Nutritional Food Molecules and Lactobacillus reuteri Surface Protein Interaction on the Bacterial Gastrointestinal Tolerance

Foods
Lactobacillus reuteri, which is present in fermented foods, can produce LPxTG motif proteins (LMPs) to help the strain resist gastrointestinal fluid environmental stress and enhance the adherence and colonizing properties.
Ao Zhang, Mingjuan Ou, Peng Wu, Kaige Zheng, Haiqian Zhang, Yixing Yu, Yuxing Guo, Tao Zhang, Daodong Pan, Zhen Wu   +9 more
doaj   +1 more source