Results 61 to 70 of about 7,912,278 (276)

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Comparison and application of small strain shear moduli from field and laboratory measurements

open access: yesYantu gongcheng xuebao, 2019
The small-strain shear modulus plays an important role in the calculations of ground seismic response and deformation in deep excavations. The values of the small strain shear modulus G0 of Shanghai soils by field and laboratory tests are investigated ...
CHEN Shao-jie 1, 2, GU Xiao-qiang 1,2, GAO Guang-yun 1, 2
doaj   +1 more source

Small

open access: yes, 2014
A proverbial objective in nanomaterial science is to construct low-dimensional nanoparticle (NP) assemblies with fascinating properties, which have shown great promise in optical, electronic and biomedical applications.
Yue, Hua   +10 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Assessment of cardiac strain in small - scale aluminium casting works.

open access: yesInternational Journal of Occupational Safety and Health, 2012
Background: The occupational health status scenario in unorganised sector is not impressive. There is a lack of awareness on occupational health and safety issues and manual labour is still obligatory.
Rajib Biswas   +3 more
doaj   +3 more sources

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Characterization of Indentation-Induced Pattern Using Full-Field Strain Measurement

open access: yes, 2011
[[abstract]]In this study DIC-based strain analysis software was successfully developed and its strain resolution lies on the order of 2.3×10-4-3.1×10-4.
Shih, Ming-Hsiang   +3 more
core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

A Modified Strain‐Wedge Model for Small Strain Rigid Piles in Sand

open access: yesEngineering Reports
This paper develops a modified strain‐wedge (MSW) model that accounts for the resistance to bending moments caused by the lateral frictional resistance and axial forces of piles in the small‐strain regime in sands and algorithmizes a finite differential ...
Yisheng Yin, Dongyuan Wang, Kai Cui
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Home - About - Disclaimer - Privacy