Results 51 to 60 of about 7,912,278 (276)

Enhancing Constitutive Models for Soils: Adding the Capability to Model Nonlinear Small Strain in Shear

Advances in Civil Engineering, 2019
The deviatoric stress-deviatoric strain relationship in soils is highly nonlinear, especially in the small strain range. However, the constitutive models which aim to replicate the small strain nonlinearity are often complex and rarely used in ...
S. Seyedan, W. T. Sołowski
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Strain-induced dielectric anisotropy of polymers for rapid and sensitive monitoring of the small elastic strain

Polymer Testing, 2023
Stretching is the most important way of forming polymer films, and the mechanism of stretch-induced structural evolution is a long-standing fundamental issue in the stretching process of polymer films. Current methods are limited in sampling frequency or
Guancheng Shen, Yuxiao Yang, Yuchao Wang, Rujian Wang, Longhui Li, Mengyuan Zhou, Muhan Zhang, Yunming Wang, Zhigao Huang, Maoyuan Li, Huamin Zhou, Yun Zhang   +11 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The small-strain stiffness of a railway ballast

Géotechnique
The large particle sizes of railway ballast and rock fill have meant that conventional techniques used to measure the small-strain stiffness of finer geomaterials have not been adopted, with the consequence that their stiffnesses are poorly defined.
Altuhafi, FN, Coop, Matthew Richard
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Constitutive behavior of Port-Said Clay under seismic and small strain static conditions

Ain Shams Engineering Journal, 2018
Port-Said Clay is very soft to firm clay deposited in the delta of an old tributary of the Nile at the east of Port-Said, Egypt. Despite the detailed characterization carried out for Port-Said Clay, no tests were carried out to measure its seismic or ...
Mohamed F. Mansour
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source