Results 221 to 230 of about 2,530,483 (266)
Some of the next articles are maybe not open access.
Small molecule probes for targeting autophagy
Nature Chemical Biology, 2021Autophagy is implicated in a wide range of (patho)physiological processes including maintenance of cellular homeostasis, neurodegenerative disorders, aging and cancer. As such, small molecule autophagy modulators are in great demand, both for their ability to act as tools to better understand this essential process and as potential therapeutics ...
Thomas Whitmarsh-Everiss, Luca Laraia
openaire +2 more sources
Targeting RNA with Small Molecules
ChemBioChem, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire +2 more sources
Optical characterization of small surface targets [PDF]
SPIE Proceedings, 2007 Present-day naval operations take place in coastal environments as well as narrow straits all over the world. Coastal environments around the world are exhibiting a number of threats to naval forces. In particular a large number of asymmetric threats can be present in environments with cluttered backgrounds as well as rapidly varying atmospheric ...
Schwering, P.B.W. +10 more
openaire +1 more source
BIOTECHS TARGET SMALL MOLECULES
Chemical & Engineering News Archive, 2007CONTINUING TO diversify their portfolios beyond protein-based therapies, the two largest biotechnology companies each signed small-molecule drug development agreements last week. In a twist, the deals allow the firms to see more data before making a bigger commitment to the drugs.
openaire +1 more source
Target small firms for antibiotic innovation
Science, 2014Once in clinical trials, antibiotics are more likely to survive than drugs in other ...
Thomas J, Hwang +2 more
openaire +2 more sources
Small-molecule quadruplex-targeted drug discovery
Bioorganic & Medicinal Chemistry Letters, 2014Repeated guanine tracts in human and other genomes can form higher-order four stranded structures, termed quadruplexes. In the human genome they have particular prevalence in telomeric and promoter regions and also in 5'-UTRs and introns. These structures, if unresolved and stabilised by small molecules, can form impediments to transcription and ...
Stephan A, Ohnmacht, Stephen, Neidle
openaire +2 more sources
Small‐Molecule Kinase‐Inhibitor Target Assessment
ChemBioChem, 2005AbstractThe identification of the cellular targets of small‐molecule protein kinase inhibitors is a significant hurdle to assessing their therapeutic potential for many diseases. Here we review several biochemical and genetics‐based approaches to identifying inhibitor targets.
Charles, Kung, Kevan M, Shokat
openaire +2 more sources
Target problem on small-world networks
Physical Review E, 2001In this work we focus on reactions on small-world networks (SWN's), disordered graphs of much recent interest. We study the target problem, since it allows an exact solution on regular lattices. On SWN's we find that the decay of the targets (for which we extend the formalism to disordered lattices) is again related to S(n), the mean number of distinct
Jasch, Florian, Blumen, Alexander
openaire +3 more sources
Targeting - Cancer — Small Molecules
2007Except for heart and coronary disease, cancer is now the principal cause of death in the Western world. Despite extensive cancer research to find improved drugs and treatments, the average chance of being cured of cancer is augmented every year by only 0.5 percent. Cancer comprises a broad group of diseases characterized by uncontrolled and independent
openaire +1 more source
Small Molecule Toxins Targeting Tumor Receptors
Current Pharmaceutical Design, 2004Targeting toxic therapeutics to tumors through receptors over expressed on the surface of cancer cells can reduce systemic toxicity and increase the effectiveness of the targeted compounds. Small molecule targeted therapeutics have a number of advantages over toxic immunoconjugates including better tumor penetration, lack of neutralizing host immune ...
Marcin, Dyba +2 more
openaire +2 more sources