Results 231 to 240 of about 10,367,950 (284)

RNA as a target for small molecules

Current Opinion in Chemical Biology, 2000
Proteins are folded to form a small binding site for catalysis or ligand recognition and this small binding site is traditionally the target for drug discovery. An alternative target for potential drug candidates is the translational process, which requires a precise reading of the entire mRNA sequence and, therefore, can be interrupted with small ...
S J, Sucheck, C H, Wong
openaire   +2 more sources

Small molecule probes for targeting autophagy

Nature Chemical Biology, 2021
Autophagy is implicated in a wide range of (patho)physiological processes including maintenance of cellular homeostasis, neurodegenerative disorders, aging and cancer. As such, small molecule autophagy modulators are in great demand, both for their ability to act as tools to better understand this essential process and as potential therapeutics ...
Thomas Whitmarsh-Everiss, Luca Laraia
openaire   +2 more sources

Targeting RNA with Small Molecules

Current Medicinal Chemistry, 2000
Therapeutic targeting of RNA is not as well-developed as with DNA and proteins, and the many structures and functions of RNA suggest that it is an underutilized target. As with DNA, RNA has heterocyclic bases and base pairs with a highly anionic backbone, but as with proteins, RNA can fold into complex tertiary structures that create unique binding ...
W D, Wilson, K, Li
openaire   +2 more sources

Small-target selection with gaze alone

Proceedings of the 2010 Symposium on Eye-Tracking Research & Applications - ETRA '10, 2010
Accessing the smallest targets in mainstream interfaces using gaze alone is difficult, but interface tools that effectively increase the size of selectable objects can help. In this paper, we propose a conceptual framework to organize existing tools and guide the development of new tools.
Henrik H. T. Skovsgaard   +3 more
openaire   +4 more sources

Small-target detection in sea clutter

IEEE Transactions on Geoscience and Remote Sensing, 2004
Sea clutter in marine surveillance radar makes the task of detecting small targets a very challenging problem. In this paper, a set of three signal processing techniques designed to suppress unwanted sea clutter radar echo and achieve target detection with no prior knowledge of the ocean and environmental conditions is presented.
Panagopolous, S., Soraghan, J.J.
openaire   +3 more sources

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