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Small molecule targeting of PTPs in cancer
The International Journal of Biochemistry & Cell Biology, 2018Protein tyrosine phosphatases (PTPs) undeniably have a central role in the development and progression of human cancers. Historically, however, PTPs have not been viewed as privileged drug targets, and progress on identifying potent, selective, and cell-active small molecule PTP inhibitors has suffered accordingly.
John S, Lazo +4 more
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RNA as a small molecule druggable target
Bioorganic & Medicinal Chemistry Letters, 2017Small molecule drugs have readily been developed against many proteins in the human proteome, but RNA has remained an elusive target for drug discovery. Increasingly, we see that RNA, and to a lesser extent DNA elements, show a persistent tertiary structure responsible for many diverse and complex cellular functions.
Noreen F, Rizvi, Graham F, Smith
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Small molecule approaches to targeting RNA
Nature Reviews ChemistryThe development of innovative methodologies to identify RNA binders has attracted enormous attention in chemical biology and drug discovery. Although antibiotics targeting bacterial ribosomal RNA have been on the market for decades, the renewed interest in RNA targeting reflects the need to better understand complex intracellular processes involving ...
Sandra Kovachka +5 more
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Therapeutic targeting of p53 by small molecules
Seminars in Cancer Biology, 2010Aberrant p53 function is one of the major requirements for tumor development. Reactivation of p53 function by small molecules is a promising strategy to combat cancer due to potent tumor suppressor activities of p53. Recent developments in p53 biology reveal that manipulation of p53 function might pave way to a long cancer-free life.
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Targeting RNA with Small Molecules
Chemical Reviews, 2008Jason R, Thomas, Paul J, Hergenrother
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Small molecules to target parasite organelle
Science, 2017Drug Development The glycosome is a peroxisome-like organelle that packages glycolytic enzymes of the parasites that cause sleeping sickness, Chagas disease, and leishmaniases. Dawidowski et al. designed small-molecule inhibitors to disrupt interactions between two of the proteins involved in peroxisome biogenesis (PEX5 and PEX14), which permit import ...
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Psf-Based Radiometry for Small Targets
Optics Communications, 2023Lei Li +5 more
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Improving target assessment in biomedical research: the GOT-IT recommendations
Nature Reviews Drug Discovery, 2020Björn Gerlach +2 more
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