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Regular and Small Target Detection
2018Although remarkable results have been achieved in the areas of object detection, the detection of small objects is still a challenging task now. The low resolution and noisy representation make small objects difficult to detect, and further recognition will be much harder. Aiming at the small objects that have regular positions, shapes, colors or other
Wenzhe Wang +3 more
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Targeting RNA with Small Molecules
ChemBioChem, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
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Small molecule targeting of SHIP1 and SHIP2
Biochemical Society Transactions, 2020Modulating the activity of the Src Homology 2 (SH2) — containing Inositol 5′-Phosphatase (SHIP) enzyme family with small molecule inhibitors provides a useful and unconventional method of influencing cell signaling in the PI3K pathway. The development of small molecules that selectively target one of the SHIP paralogs (SHIP1 or SHIP2) as well as ...
William G. Kerr +4 more
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In Silico Target Prediction for Small Molecules
2018Drugs modulate disease states through their actions on targets in the body. Determining these targets aids the focused development of new treatments, and helps to better characterize those already employed. One means of accomplishing this is through the deployment of in silico methodologies, harnessing computational analytical and predictive power to ...
Ryan Byrne, Gisbert Schneider
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Small target detection by morphological operations
2015 23nd Signal Processing and Communications Applications Conference (SIU), 2015Automatic target detection has an important application field in today's missile technology. Therefore, there are many studies in this field. In this context, morphological operation (MO) based methods were firstly investigated and tested on the prepared scenarios.
Ozan Yardimci +2 more
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Small Molecules Targeting the Transmembrane Domain
Journal of Medicinal ChemistryAbstract The transmembrane domain (TMD) of membrane proteins has emerged as a promising yet challenging target for drug discovery due to its hydrophobic nature and complex structure. Recent advances in structural biology and computational tools have provided unprecedented insights of TMDs, revealing new opportunities for therapeutic ...
Yibo Wang, Xiaohui Wang
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Small Bowel Target Devices and Techniques
Gastrointestinal Endoscopy Clinics of North America, 2017The small bowel is a prime target for bariatric and metabolic endoscopic therapies. New insights into the mechanisms of action of surgical therapies have led to new endoscopic therapies for obesity, type 2 diabetes mellitus, and the metabolic syndrome. The development of endoluminal sleeves that bypass the proximal duodenum have replicated some of the ...
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Target small firms for antibiotic innovation
Science, 2014Once in clinical trials, antibiotics are more likely to survive than drugs in other ...
Thomas J, Hwang +2 more
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Algorithms on Graphs with Small Dominating Targets
2006A dominating target of a graph G=(V,E) is a set of vertices T s.t. for all W⊆V, if T⊆W and induced subgraph on W is connected, then W is a dominating set of G. The size of the smallest dominating target is called dominating target number of the graph, dt(G).
Divesh Aggarwal +2 more
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Targeting components of epigenome by small molecules
Archives of Pharmacal Research, 2014The diverse epigenetic modifications regulate the gene expression and determine the cellular identity. Pioneering work over the past decades has highlighted that these epigenetic regulations establish normal development but also contribute various diseases.
Jueng Soo, You, Jeong Hwan, Han
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