Results 241 to 250 of about 6,330,702 (296)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Fully Autonomous Real-Time Defect Detection for Power Distribution Towers: A Small Target Defect Detection Method Based on YOLOv11n. [PDF]

Sensors (Basel)
Zhang J, Chen S, Wang W, Wang Q.
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Small target detection in coal mine underground based on improved RTDETR algorithm. [PDF]

Sci Rep
Tian F, Song C, Liu X.
europepmc   +1 more source

CSW-YOLO: A traffic sign small target detection algorithm based on YOLOv8. [PDF]

PLoS One
Shen Q, Li Y, Zhang Y, Zhang L, Liu S, Wu J.   +5 more
europepmc   +1 more source

A Lightweight Model for Small-Target Pig Eye Detection in Automated Estrus Recognition. [PDF]

Animals (Basel)
Zhao M, Duan Y, Gao T, Gao X, Hu G, Cao R, Liu Z.   +6 more
europepmc   +1 more source

Small target detection in UAV view based on improved YOLOv8 algorithm. [PDF]

Sci Rep
Zhang X, Zuo G.
europepmc   +1 more source

LI-YOLOv8: Lightweight small target detection algorithm for remote sensing images that combines GSConv and PConv. [PDF]

PLoS One
Yan P, Qi X, Jiang L.
europepmc   +1 more source

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Targeting RNA with Small Molecules

Current Medicinal Chemistry, 2000
Therapeutic targeting of RNA is not as well-developed as with DNA and proteins, and the many structures and functions of RNA suggest that it is an underutilized target. As with DNA, RNA has heterocyclic bases and base pairs with a highly anionic backbone, but as with proteins, RNA can fold into complex tertiary structures that create unique binding ...
W D, Wilson, K, Li
openaire   +2 more sources