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Small Bowel Target Devices and Techniques
Gastrointestinal Endoscopy Clinics of North America, 2017The small bowel is a prime target for bariatric and metabolic endoscopic therapies. New insights into the mechanisms of action of surgical therapies have led to new endoscopic therapies for obesity, type 2 diabetes mellitus, and the metabolic syndrome. The development of endoluminal sleeves that bypass the proximal duodenum have replicated some of the ...
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Small molecules to target parasite organelle
Science, 2017Drug Development The glycosome is a peroxisome-like organelle that packages glycolytic enzymes of the parasites that cause sleeping sickness, Chagas disease, and leishmaniases. Dawidowski et al. designed small-molecule inhibitors to disrupt interactions between two of the proteins involved in peroxisome biogenesis (PEX5 and PEX14), which permit import ...
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Small molecule approaches to targeting RNA
Nature Reviews ChemistryThe development of innovative methodologies to identify RNA binders has attracted enormous attention in chemical biology and drug discovery. Although antibiotics targeting bacterial ribosomal RNA have been on the market for decades, the renewed interest in RNA targeting reflects the need to better understand complex intracellular processes involving ...
Sandra Kovachka +5 more
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Aim Small, Miss Small: Targeting International Small-Cap Stocks
2015If you go target shooting with an instructor, one of the more useful pieces of advice you may get is “aim small, miss small.” The thinking is that if you point at a target, say, a mugger on the street, and miss, you could be in big trouble. Hello, angry mugger; good-bye, wallet.
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Targeting RNA with Small Molecules
Chemical Reviews, 2008Jason R, Thomas, Paul J, Hergenrother
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Cancer epigenetics in clinical practice
Ca-A Cancer Journal for Clinicians, 2023Veronica Davalos, Manel Esteller
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