Results 111 to 120 of about 11,225,352 (286)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A simple and efficient saliency extraction method based on multi-scale horizon-directional filter for infrared dim small target detection

, 2011
This paper presents a simple and computationally efficient saliency extraction method for detecting dim small target from single frame in heterogeneous background. The proposed method is based on background subtraction (BS), which identifies targets from
Xia RB(夏仁波), Zhao JB(赵吉宾), Hui B(惠斌), Chang Z(常铮), Zhou GC(周广超)   +4 more
core  

Semantic-Guided Enhanced UIU-Net for Infrared Small Target Detection

Photonics
Infrared small-target detection is commonly implemented as binary pixel-level segmentation and localization but remains challenging because targets occupy very few pixels and are embedded in complex backgrounds.
Xiuli Luo, Lixiang Shao, Zhengyang Huang, Liming Wang, Yu Zhai, Bin Liu, Yaoxia Zhao   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

MPE-YOLO: enhanced small target detection in aerial imaging

Scientific Reports
Aerial image target detection is essential for urban planning, traffic monitoring, and disaster assessment. However, existing detection algorithms struggle with small target recognition and accuracy in complex environments.
Jia Su, Yichang Qin, Ze Jia, Ben Liang
doaj   +1 more source

IST-DETR: Improved DETR for Infrared Small Target Detection

IEEE Access
In this study, an Infrared Small-Target Detection Transformer (IST-DETR) is introduced, a novel model specifically designed to tackle the challenges of low-resolution infrared images and small target scales.
Li Zhao, Jianlong Wang, Yunhao Chen, Qian Yin, Guyao Rong, Sida Zhou, Jianing Tang   +6 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A model for search and detection of small targets

Journal of Vision, 2010
Computational models predicting the distribution of the time to detection of small targets on a display are being developed to improve workstation designs. Search models usually contain bottom-up processes, such as a saliency map, and top-down processes, such as a priori distributions over the possible locations to be searched.
openaire   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source