Results 101 to 110 of about 1,135,336 (304)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Dual Enhancement Network for Infrared Small Target Detection

Applied Sciences
Infrared small target detection (IRSTD) is crucial for applications in security surveillance, unmanned aerial vehicle identification, military reconnaissance, and other fields.
Xinyi Wu, Xudong Hu, Huaizheng Lu, Chaopeng Li, Lei Zhang, Weifang Huang   +5 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Small target detection and window adaptive tracking based on continuous frame images in visible light background [PDF]

, 2020
Zheng Wang, Jianping Zeng, Xiaoli Xie, Wuming Wu, Shengli Chang   +4 more
openalex   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

IST-DETR: Improved DETR for Infrared Small Target Detection

IEEE Access
In this study, an Infrared Small-Target Detection Transformer (IST-DETR) is introduced, a novel model specifically designed to tackle the challenges of low-resolution infrared images and small target scales.
Li Zhao, Jianlong Wang, Yunhao Chen, Qian Yin, Guyao Rong, Sida Zhou, Jianing Tang   +6 more
doaj   +1 more source

A pixel-level local contrast measure for infrared small target detection

, 2021
Zhaobing Qiu, Yong Ma, Fan Fan, Jun Huang, Minghui Wu, Xiaoguang Mei   +5 more
openalex   +1 more source

A Study on Wireless Capsule Endoscopy for Small Intestinal Lesions Detection Based on Deep Learning Target Detection [PDF]

, 2020
Zhiguo Xiao, Feng Li
openalex   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source