Results 1 to 10 of about 37,476 (270)

Broad Spectrum Identification of Cellular Small Ubiquitin-related Modifier (SUMO) Substrate Proteins* [PDF]

Journal of Biological Chemistry, 2004
Reversible covalent modification of proteins with a small ubiquitin-related modifier (SUMO) is emerging as an important system contributing to dynamic regulation of protein function. To enhance our understanding of the cell regulatory systems impacted by
Yingming Zhao, Sung Won Kwon, A. Anselmo, Kiran J. Kaur, M. White   +4 more
semanticscholar   +4 more sources

Small ubiquitin-related modifier (SUMO)-1, SUMO-2/3 and SUMOylation are involved with centromeric heterochromatin of chromosomes 9 and 1 and proteins of the synaptonemal complex during meiosis in men [PDF]

Human Reproduction, 2008
BACKGROUND Post-transcriptional modification by SUMOylation is involved in numerous cellular processes including human spermatogenesis. For human male meiosis, we previously showed that the small ubiquitin-related modifier-1 (SUMO-1) protein localizes to
Petrice W. Brown, Keumsil Hwang, P. Schlegel, P. Morris   +3 more
semanticscholar   +4 more sources

Regulation of Homeodomain-interacting Protein Kinase 2 (HIPK2) Effector Function through Dynamic Small Ubiquitin-related Modifier-1 (SUMO-1) Modification* [PDF]

Journal of Biological Chemistry, 2005
Homeodomain-interacting protein kinase 2 (HIPK2) is involved in transcriptional regulation, growth suppression, and apoptosis. Previous reports showed that HIPK2 can signal cell death via p53, and independently of p53 by activating the c-Jun NH2-terminal
T. Hofmann, E. Jaffray, Nicole Stollberg, R. Hay, H. Will   +4 more
semanticscholar   +5 more sources

Small ubiquitin-related modifier (SUMO) pathway-mediated enhancement of human cytomegalovirus replication correlates with a recruitment of SUMO-1/3 proteins to viral replication compartments.

Journal of General Virology, 2013
Recent studies have suggested that the small ubiquitin-related modifier (SUMO) conjugation pathway may play an important role in intrinsic antiviral resistance and thus for repression of herpesviral infections. In particular, it was shown that the herpes simplex virus type-1 regulatory protein ICP0 acts as a SUMO-targeted ubiquitin ligase (STUbL ...
Myriam Scherer, Nina Reuter, Nadine Wagenknecht, Victoria Otto, H. Sticht, T. Stamminger   +5 more
semanticscholar   +4 more sources

Functional Heterogeneity of Small Ubiquitin-related Protein Modifiers SUMO-1 versus SUMO-2/3 [PDF]

Journal of Biological Chemistry, 2000
Post-translational modification marked by the covalent attachment of the ubiquitin-like protein SUMO-1/SMT3C has been implicated in a wide variety of cellular processes. Recently, two cDNAs encoding proteins related to SUMO-1 have been identified in human and mouse. The functions and regulation of these proteins, known as SUMO-2/SMT3A and SUMO-3/SMT3B,
H, Saitoh, J, Hinchey
openaire   +4 more sources

Tripartite Motif-Containing Protein 28 Is a Small Ubiquitin-Related Modifier E3 Ligase and Negative Regulator of IFN Regulatory Factor 7 [PDF]

The Journal of Immunology, 2011
Abstract IFN regulatory factor 7 (IRF7) is a potent transcription factor of type I IFNs and IFN-stimulated genes and is known as the master regulator of type I IFN-dependent immune responses. Because excessive responses could harm the host, IRF7 itself is delicately regulated at the transcriptional, translational, and posttranslational ...
Qiming, Liang, Hongying, Deng, Xiaojuan, Li, Xianfang, Wu, Qiyi, Tang, Tsung-Hsien, Chang, Hongzhuang, Peng, Frank J, Rauscher, Keiko, Ozato, Fanxiu, Zhu   +9 more
openaire   +3 more sources

Post‐ovulatory aging is associated with altered patterns for small ubiquitin‐like modifier (SUMO) proteins and SUMO‐specific proteases

The FASEB Journal, 2023
Mammalian oocytes are ovulated arrested at metaphase of the second meiotic division. If they are not fertilized within a short period, the oocyte undergoes several progressive morphological, structural, and molecular changes during a process called ...
W. Feitosa, P. Morris
semanticscholar   +1 more source

A Chemical and Enzymatic Approach to Study Site-Specific Sumoylation. [PDF]

, 2015
A variety of cellular pathways are regulated by protein modifications with ubiquitin-family proteins. SUMO, the Small Ubiquitin-like MOdifier, is covalently attached to lysine on target proteins via a cascade reaction catalyzed by E1, E2, and E3 enzymes.
Albuquerque, Claudio P, Corbett, Kevin D, Fu, Ting, Ma, Shawn, Yeung, Eyan, Zhou, Huilin   +5 more
core   +14 more sources

Small ubiquitin-related modifier 2 affects the intracellular survival of Brucella abortus 2308 by regulating activation of the NF-κB pathway

Innate Immunity, 2020
Brucella is a genus of Gram-negative intracellular pathogens that cause animal and human diseases. Brucella survival and replication inside immune cells is critical for the establishment of chronic infections.
Yueli Wang, J. Xi, Peng Wu, Huan Zhang, X. Deng, Yong Wang, Zhongchen Ma, Jihai Yi, Chuangfu Chen   +8 more
semanticscholar   +1 more source

RanBP2-Mediated SUMOylation Promotes Human DNA Polymerase Lambda Nuclear Localization and DNA Repair [PDF]

, 2020
Cellular DNA is under constant attack by a wide variety of agents, both endogenous and exogenous. To counteract DNA damage, human cells have a large collection of DNA repair factors. Among them, DNA polymerase lambda (Polλ) stands out for its versatility,
Cortés Ledesma, Felipe, García Domínguez, Mario, Herrero Ruiz, Andrés M., Moreno Oñate, Marta, Ruiz Pérez, José Francisco   +4 more
core   +1 more source