Results 31 to 40 of about 37,476 (270)

Global Identification of Small Ubiquitin-related Modifier (SUMO) Substrates Reveals Crosstalk between SUMOylation and Phosphorylation Promotes Cell Migration

Molecular & Cellular Proteomics, 2018
Proteomics studies have revealed that SUMOylation is a widely used post-translational modification (PTM) in eukaryotes. However, how SUMO E1/2/3 complexes use different SUMO isoforms and recognize substrates remains largely unknown.
I. Uzoma, Jianfei Hu, Eric Cox, S. Xia, Jianying Zhou, Hee-Sool Rho, Catherine M. Guzzo, Corry Paul, Olutobi Ajala, C. R. Goodwin, J. Jeong, Cedric Moore, Hui Zhang, P. Meluh, S. Blackshaw, M. Matunis, Jiang Qian, Heng Zhu   +17 more
semanticscholar   +1 more source

Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking. [PDF]

, 2018
Receptor tyrosine kinases (RTKs) are membrane-based sensors that enable rapid communication between cells and their environment. Evidence is now emerging that interdependent regulatory mechanisms, such as membrane trafficking, ubiquitination, proteolysis
Basagiannis, Girnita, Jahangiri, Lund, McGrath, Ott, Smith, Wiborg   +7 more
core   +5 more sources

Small Ubiquitin-related Modifier (SUMO) Binding Determines Substrate Recognition and Paralog-selective SUMO Modification*

Journal of Biological Chemistry, 2008
Small ubiquitin-related modifiers (SUMOs) regulate diverse cellular processes through their covalent attachment to target proteins. Vertebrates express three SUMO paralogs: SUMO-1, SUMO-2, and SUMO-3 (SUMO-2 and SUMO-3 are ∼96% identical and referred to ...
Jianmei Zhu, Shanshan Zhu, Catherine M. Guzzo, N. Ellis, K. Sung, C. Choi, M. Matunis   +6 more
semanticscholar   +1 more source

Ubiquitin‐Related Modifier SUMO1 and Nucleocytoplasmic Transport

Traffic, 2002
A. Pichler, F. Melchior
semanticscholar   +3 more sources

The SUMO Ligase Protein Inhibitor of Activated STAT 1 (PIAS1) is a constituent PML-NB protein that contributes to the intrinsic antiviral immune response to herpes simplex virus 1 (HSV-1) [PDF]

, 2016
Aspects of intrinsic antiviral immunity are mediated by promyelocytic leukaemia (PML)-nuclear body (PML-NB) constituent proteins. During herpesvirus infection, these antiviral proteins are independently recruited to nuclear domains that contain infecting
Boutell, Chris, Brown, James R., Charman, Matthew, Conn, Kristen L., Grant, Kyle, McFarlane, Steven, Tong, Lily, Wasson, Peter   +7 more
core   +1 more source

Small ubiquitin-related modifier 2/3 interacts with p65 and stabilizes it in the cytoplasm in HBV-associated hepatocellular carcinoma

BMC Cancer, 2015
BackgroundSUMOylation, an important post-translational modification, associates with the development of hepatocellular carcinoma (HCC). p65, one of the most important subunits of NF-κB, is a key regulator in the development of HCC and has been reported ...
Jun Liu, Manqi Sha, Qianfeng Wang, Yong Ma, X. Geng, Yufeng Gao, Lijie Feng, Yujun Shen, Yuxian Shen   +8 more
semanticscholar   +1 more source

SIZ1 Controls Cell Growth and Plant Development in Arabidopsis Through Salicylic Acid [PDF]

, 2009
The post-translational conjugation of small ubiquitin-related modifiers (SUMOs) to other proteins is involved in regulation of many processes in eukaryotic development; although its role in plant development is beginning to be dissected.
Hasegawa Paul M., Lee Jiyoung, Miura Kenji, Miura Tomoko, 三浦 謙治   +4 more
core   +1 more source

In Vitro Studies Reveal a Sequential Mode of Chain Processing by the Yeast SUMO (Small Ubiquitin-related Modifier)-specific Protease Ulp2

Journal of Biological Chemistry, 2015
Background: Modification of proteins with small ubiquitin-related modifier has many important functions in cell biology. Results: Substrate-attached SUMO chains are processed by the yeast enzymes Ulp1 and Ulp2 via different mechanisms.
J. Eckhoff, R. J. Dohmen
semanticscholar   +1 more source

Post-transcriptional and post-translational regulations of drought and heat response in plants: a spider’s web of mechanisms [PDF]

, 2015
Drought and heat tolerance are complex quantitative traits. Moreover, the adaptive significance of some stress-related traits is more related to plant survival than to agronomic performance.
Anna M. Mastrangelo, Cristina Crosatti, Davide Guerra, Elisabetta Mazzucotelli, Erica Mica, Hamid H. Khoshro   +5 more
core   +2 more sources

Intense Resistance Exercise Promotes the Acute and Transient Nuclear Translocation of Small Ubiquitin-Related Modifier (SUMO)-1 in Human Myofibres

International Journal of Molecular Sciences, 2016
Protein sumoylation is a posttranslational modification triggered by cellular stress. Because general information concerning the role of small ubiquitin-related modifier (SUMO) proteins in adult skeletal muscle is sparse, we investigated whether SUMO-1 ...
S. Gehlert, F. Klinz, L. Willkomm, T. Schiffer, F. Suhr, W. Bloch   +5 more
semanticscholar   +1 more source