Results 51 to 60 of about 37,476 (270)

UBP12 and UBP13 negatively regulate the activity of the ubiquitin-dependent peptidases DA1, DAR1 and DAR2 [PDF]

, 2020
Protein ubiquitination is a very diverse post-translational modification leading to protein degradation or delocalization, or altering protein activity. In Arabidopsis thaliana, two E3 ligases, BIG BROTHER (BB) and DA2, activate the latent peptidases DA1,
Chen, Ying, De Jaeger, Geert, De Milde, Liesbeth, De Vleeschhauwer, Valerie, Eeckhout, Dominique, Gevaert, Kris, Inzé, Dirk, Natran, Annelore, Persiau, Geert, Vanhaeren, Hannes, Vermeersch, Mattias   +10 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Global analysis of SUMO chain function reveals multiple roles in chromatin regulation. [PDF]

, 2013
Like ubiquitin, the small ubiquitin-related modifier (SUMO) proteins can form oligomeric chains, but the biological functions of these superstructures are not well understood. Here, we created mutant yeast strains unable to synthesize SUMO chains (smt3(
Andrews, Brenda J, Boone, Charles, Brown, Grant W, Costanzo, Michael, Giaever, Guri, Johnson, Erica S, Lewicki, Megan C, Nislow, Corey, Raught, Brian, Srikumar, Tharan, Tkach, Johnny M, Tsui, Kyle, van Bakel, Harm   +12 more
core   +2 more sources

Knockdown of ubiquitin-like modifier-activating enzyme 2 promotes apoptosis of clear cell renal cell carcinoma cells

Cell Death and Disease, 2021
Small ubiquitin-related modifier (SUMO) proteins are involved in the development of tumors. Ubiquitin-like modifier-activating enzyme 2 (UBA2) is an important member of the SUMO modification system; however, its role in clear cell renal cell carcinoma ...
Guoxi Zhang, Junrong Zou, Jinglin Shi, Biao Qian, Kaiyan Qiu, Quanliang Liu, T. Xie, Zhihua He, Hui Xu, Y. Liao, Yuting Wu, Yanmin Li, Guancheng Xiao, Yuanhu Yuan, R. Xiao, Gengqing Wu, X. Zou   +16 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4 [PDF]

, 2014
The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response.
A Hershko, A Plechanovova, A Plechanovova, A Rojas-Fernandez, AM Weissman, AT Brunger, AT Namanja, CC Chang, CH Cheng, CM Hecker, CM Pickart, CW Liew, D Reverter, E Escobar-Cabrera, ES Johnson, F Ikeda, FM Lin, GNB Yip, H Sun, HD Ulrich, HY Sun, I Matic, J Marchant, J Prudden, J Song, J Song, J Xia, JD Schnell, JH Hurley, JL Battiste, JS Thrower, K Keusekotten, L Deng, M Ottiger, M Zweckstetter, MH Tatham, MH Tatham, MJ Eddins, MJ Eddins, MR Hansen, MS Rodriguez, N Sekiyama, N Zhang, O Kerscher, O Kerscher, Q Wang, R Bruderer, R Lescasse, R Mahajan, R Varadan, RT Hay, S-R Tzeng, SC Panchal, W Rieping, W-C Huang, XD Zhang, Y Shen, Y Xie   +57 more
core   +4 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Ecm11-Gmc2 complex promotes synaptonemal complex formation through assembly of transverse filaments in budding yeast [PDF]

, 2013
During meiosis, homologous chromosomes pair at close proximity to form the synaptonemal complex (SC). This association is mediated by transverse filament proteins that hold the axes of homologous chromosomes together along their entire length. Transverse
AB Zavec, AB Zavec, AJ Macqueen, AV Smith, B Kemp, B Rockmill, B Rockmill, Bilge Argunhan, BL Schneider, CE de Carvalho, CH Cheng, CM Lake, CS Eichinger, DK Bishop, E Alani, E Bolcun-Filas, F Storici, FM Lin, G Hamer, GA Brar, GV Börner, GW Hooker, H Tsubouchi, H Tsubouchi, H Tsubouchi, Hideo Tsubouchi, J Perry, JE Falk, JL Gerton, JR Hudson, L Newnham, M Lussier, M Petronczki, M Primig, M Shinohara, M Sym, M Sym, Martina Dvorackova, MN Gladstone, MS Longtine, N Hunter, Neil Humphryes, P James, PR Chua, R. Scott Hawley, S Agarwal, S Chu, S Farmer, S Schramm, SL Page, SY Chen, T Tsubouchi, T Tsubouchi, T Tsubouchi, Wing-Kit Leung, Y Costa, Yaroslav Terentyev   +56 more
core   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source