Results 71 to 80 of about 37,476 (270)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Transcription factor Sp3 as target for SUMOylation in vivo [PDF]

, 2005
A group of sequence-specific DNA-binding proteins related to the transcription factor Sp1 (specificity protein 1) has been implicated in the regulation of many different genes, since binding sites for these transcription factors (GC/GT boxes) are a ...
Renkawitz-Pohl, Renate (Prof. Dr.), Rischitor, Grigore   +1 more
core   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

Advanced Science, EarlyView.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu, Lili Su, Shuiping Gao, Wenting Liu, Hongxia Wang   +4 more
wiley   +1 more source

SUMOylation: novel neuroprotective approach for Alzheimer's disease? [PDF]

, 2015
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized in the brain by the formation of amyloid-beta (Aβ)-containing plaques and neurofibrillary tangles containing the microtubule-associated protein tau.
Cimarosti, Helena, Hoppe, Juliana B., Salbego, Christianne G.   +2 more
core   +1 more source

RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis

Advanced Science, EarlyView.
Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao, Chao Ren, Li‐Yu Zheng, Jing‐Yan Li, Wen‐Feng Wu, Yu‐Xuan Li, Li‐Xue Wang, Yu Duan, Lu Wang, Shuang‐Qing Liu, Peng‐Yi He, Peng‐Yue Zhao, Sen Tong, Zhi‐Xuan Li, Tuo Zhang, Meng‐Yao Wu, Shu‐Ting Wei, Ning Dong, Yao Wu, Hui Zhang, Xiao‐Mei Zhu, Zi‐Cheng Zhang, Guo‐Sheng Wu, Zhao‐Fan Xia, Xiao‐Hui Du, Hong‐Jun Kang, Zui Zou, Dao‐Lin Tang, Yong‐Ming Yao   +28 more
wiley   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies [PDF]

, 2019
Nuclear factor E2-related factor 2 (NRF2), a transcription factor, is a master regulator of an array of genes related to oxidative and electrophilic stress that promote and maintain redox homeostasis. NRF2 function is well studied in in vitro, animal and
Deeni, Yusuf Y., Kankia, Ibrahim H., Langdon, Simon P., Paramasivan, Poornima   +3 more
core   +3 more sources

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

SUMOylation and calcium signalling: potential roles in the brain and beyond [PDF]

, 2017
Small ubiquitin-like modi er (SUMO) conjugation (or SUMOylation) is a post-translational protein modi cation implicated in alterations to protein expression, localization and func- tion. Despite a number of nuclear roles for SUMO being well characterized,
Abeywardana, Anderson, Bean, Benson, Bernt, Berridge, Bezprozvanny, Binda, Bonifati, Bourinet, Brawek, Brittain, Broers, Caraci, Cartwright, Chandra, Chandra, Chang, Cho, Cimarosti, Cimarosti, Cizkova, Clapham, Craig, Cuomo, Dai, Dai, Davila, Deng, Di-Bacco, Dib-Hajj, Dolmetsch, Dorval, Dorval, Doyle, Dustrude, Dutting, Eckermann, Es-Salah-Lamoureux, Feliciangeli, Feligioni, Felix, Flavell, Flotho, Gareau, Geoffroy, Girach, Golbe, Gong, Gong, Guerra de Souza, Guo, Guo, Gupta, Haass, Hagiwara, Hang, Harris, Hay, Hendriks, Hendriks, Henley, Hermann, Hickey, Hietakangas, Jagodic, Janer, Jardin, Johnson, Ju, Kaeser, Kang, Kho, Kho, Kim, Kim, Kolli, Konopacki, Krumova, Kruse, Lee, Lee, Lee, Li, Liang, Lima, Lisman, Long, Loriol, Loriol, Lory, Maejima, Marger, Maroteaux, Martin, Matsuzaki, Matsuzaki, McMillan, Melchior, Mendler, Meyer, Mezler, Miljanich, Molinaro, Müller, Nacerddine, Nayak, Nistico, Nowycky, Oh, Oh, Oliveira, Pal, Plant, Plant, Plant, Putzier, Qi, Rajan, Rauck, Rcom-H’cheo-Gauthier, Reverter, Riquelme, Rodriguez, Ronzitti, Rougier, Rush, Sampson, Sarge, Schorova, Schäfer, Selkoe, Shalizi, Shen, Shinbo, Silveirinha, Sinha, Smith, Sozen, Stapels, Steinlein, Surmeier, Südhof, Taira, Tanabe, Tang, Thornton, Um, Walsh, Wang, Wang, Wang, Wang, Wang, Waxman, Weingarten, Wheeler, Wheeler, Wilkins, Wilson, Wong, Wong, Woodcock, Xu, Xu, Yang, Yun, Zamponi, Zamponi, Zhang, Zhang, Zhang, Zhao, Zhu, Zhuchenko, Zunino, Zündorf   +176 more
core   +1 more source