Results 1 to 10 of about 1,601,455 (409)

Proteostasis in Cerebral Small Vessel Disease [PDF]

Frontiers in Neuroscience, 2019
Maintaining the homeostasis of proteins (proteostasis) by controlling their synthesis, folding and degradation is a central task of cells and tissues. The gradual decline of the capacity of the various proteostasis machineries, frequently in combination ...
Christof Haffner
doaj   +7 more sources

Small vessel disease burden and functional brain connectivity in mild cognitive impairment [PDF]

Cerebral Circulation - Cognition and Behavior
Background: The role of small vessel disease in the development of dementia is not yet completely understood. Functional brain connectivity has been shown to differ between individuals with and without cerebral small vessel disease.
Sofia Marcolini, Jaime D. Mondragón, Esther E. Bron, Geert J. Biessels, Jurgen A.H.R. Claassen, Janne M. Papma, Huub Middelkoop, Rudi A.J.O. Dierckx, Ronald J.H. Borra, Inez H.G.B. Ramakers, Wiesje M. van der Flier, Natasha M. Maurits, Peter P. De Deyn   +12 more
doaj   +10 more sources

NIHSS Scores in Ischemic Small Vessel Disease: A Study in CADASIL [PDF]

, 2012
Background: The National Institutes of Health Stroke Scale (NIHSS) is widely used to measure neurological deficits, evaluate the effectiveness of treatment and predict outcome in acute ischemic stroke.
Ming Yao, Dominique Hervé, Nassira Allili, Éric Jouvent, Marco Duering, Martin Dichgans, Hugues Chabriat   +6 more
openalex   +3 more sources

Cerebral Small Vessel Disease and Alzheimer's Disease: A Review

Frontiers in Neurology, 2020
Alzheimer's disease (AD) is the most common cause of dementia. Despite this, clear pathophysiology for AD has not been confirmed, and effective treatments are still not available.
Hae Won Kim, Jeongho Hong, Jae Cheon Jeon   +2 more
doaj   +2 more sources

Quantitative comparison of CSVD imaging markers between patients with possible amyloid small vessel disease and with non-amyloid small vessel disease [PDF]

NeuroImage: Clinical
The spatial distribution patterns of cerebral microbleeds are associated with different types of cerebral small vessel disease (CSVD). This study aims to examine the disparities in brain imaging markers of CSVD among patients diagnosed with possible ...
Chun-Qiang Lu, Ying Liu, Jia-Rong Huang, Meng-Shuang Li, Yan-Shuang Wang, Yan Gu, Di Chang   +6 more
doaj   +2 more sources

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

Lancet Neurology, 2013
Joanna M. Wardlaw, Eric E. Smith, Geert Jan Biessels, Charlotte Cordonnier, Franz Fazekas, Richard Frayne, Richard I. Lindley, John T. O’Brien, Frederik Barkhof, Oscar Benavente, Sandra E. Black, Carol Brayne, Monique M.B. Breteler, Hugues Chabriat, Charles DeCarli, Frank‐Erik de Leeuw, Fergus Doubal, Marco Duering, Nick C. Fox, Steven M. Greenberg, Vladimir Hachinski, Ingo Kilimann, Vincent Mok, Robert van Oostenbrugge, Leonardo Pantoni, Oliver Speck, Blossom C. M. Stephan, Stefan Teipel, Anand Viswanathan, David J. Werring, Christopher Chen, Colin Smith, Mark A. van Buchem, Bo Norrving, Philip B. Gorelick, Martin Dichgans   +35 more
openalex   +3 more sources

Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease

Molecular Neurodegeneration, 2023
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular injuries in cerebral large and small vessels and is a key driver of age-related cognitive decline.
Yasuteru Inoue, Francis Shue, G. Bu, T. Kanekiyo   +3 more
semanticscholar   +1 more source

Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease

JAMA Neurology, 2023
Key Points Question Can modulators of cerebrovascular endothelial function, including isosorbide mononitrate (ISMN; a nitric oxide donor) and cilostazol (a phosphodiesterase-3 inhibitor), improve long-term outcomes after lacunar ischemic stroke? Findings
J. Wardlaw, L. Woodhouse, I. Mhlanga, K. Oatey, A. Heye, J. Bamford, V. Cvoro, F. Doubal, T. England, Ahamad Hassan, A. Montgomery, J. O'Brien, C. Roffe, N. Sprigg, D. Werring, P. Bath   +15 more
semanticscholar   +1 more source

Cerebral Small Vessel Disease, Hypertension, and Vascular Contributions to Cognitive Impairment and Dementia

HYPERTENSION, 2023
Hypertension-associated cerebral small vessel disease is a common finding in older people. Strongly associated with age and hypertension, small vessel disease is found at autopsy in over 50% of people aged ≥65 years, with a spectrum of clinical ...
A. Hainsworth, Hugh S. Markus, Julie A. Schneider   +2 more
semanticscholar   +1 more source

Cerebral small vessel disease: Recent advances and future directions

International Journal of Stroke, 2022
Cerebral small vessel disease (SVD) causes lacunar stroke and intracerebral hemorrhage, and is the most common pathology underlying vascular cognitive impairment.
H. Markus, Frank Erik de Leeuw
semanticscholar   +1 more source