Results 31 to 40 of about 1,601,455 (409)

MTHFR C677T genotype and small vessel disease [PDF]

, 2016
BACKGROUND AND PURPOSE: Elevated plasma homocysteine levels are associated with stroke. However, this might be a reflection of bias or confounding because trials have failed to demonstrate an effect from homocysteine lowering in stroke patients, although
Ahamad Hassan, Cathie Sudlow, Christopher Levi, Giorgio Boncoraglio, Hugh S. Markus, James Meschia, Jane Maguire, Jonathan Rosand, Loes C.A. Rutten-Jacobs, Martin Dichgans, Matthew Traylor, Natalia S. Rost, Peter M. Rothwell, Poneh Adib-Samii, Steve Bevan, Tran T, Vincent Thijs   +16 more
core   +8 more sources

Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review.

JAMA Neurology, 2022
Importance Cerebral small vessel disease (SVD) causes a quarter of strokes and is the most common pathology underlying vascular cognitive impairment and dementia. An important step to developing new treatments is better trial methodology.
H. Markus, W. M. van der Flier, E. Smith, P. Bath, G. Biessels, E. Briceño, Amy Brodtman, H. Chabriat, Christopher P L H Chen, F. de Leeuw, M. Egle, A. Ganesh, Marios K. Georgakis, R. Gottesman, S. Kwon, L. Launer, Vincent C. T. Mok, J. O'Brien, Lois Ottenhoff, S. Pendlebury, E. Richard, P. Sachdev, R. Schmidt, Melanie Springer, Stefan Tiedt, J. Wardlaw, A. Verdelho, A. Webb, D. Werring, M. Duering, D. Levine, M. Dichgans   +31 more
semanticscholar   +1 more source

HTRA1-related autosomal dominant cerebral small vessel disease

Chinese Medical Journal, 2021
. Background. Homozygous or compound heterozygous mutations in high temperature requirement serine peptidase A1 (HTRA1) gene are responsible for cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL ...
Jing-Yi Liu, Yi-Cheng Zhu, Li-Xin Zhou, Yan-Ping Wei, Chen-Hui Mao, Li-Ying Cui, Bin Peng, Ming Yao, Xin Chen   +8 more
doaj   +1 more source

Inflammatory biomarkers and cerebral small vessel disease: a community-based cohort study

Stroke and vascular neurology, 2022
Background and purpose Although inflammation has been proposed to be a candidate risk factor for cerebral small vessel disease (CSVD), previous findings remain largely inconclusive and vary according to disease status and study designs. The present study
Dingding Zhang, Yuan Cao, Jingwei Mu, Yiming Liu, F. Gao, F. Han, F. Zhai, Li-xin Zhou, J. Ni, M. Yao, Ming-Li Li, Z. Jin, Shu-yang Zhang, L. Cui, Yong Shen, Yicheng Zhu   +15 more
semanticscholar   +1 more source

Collagen-based scaffolds for tissue engineering of small-diameter blood vessels [PDF]

, 2005
Atherosclerotic vascular disease, including peripheral and coronary artery disease, is the main cause of morbidity and mortality in the Western society.
Buttafoco, Laura
core   +8 more sources

Homocysteine in cerebrovascular disease: An independent risk factor for subcortical vascular encephalopathy [PDF]

, 2001
Hyperhomocysteinemia is a risk factor for obstructive large-vessel disease. Here, we studied plasma concentrations of homocysteine and vitamins in patients suffering from subcortical vascular encephalopathy (SVE), a cerebral small-vessel disease leading ...
Aufenanger, Johannes, Bertsch, Thomas, Casarin, Wendy, Fassbender, Klaus, Höly, Sabine, Kuehl, Sandra, Mielke, Orell, Muehlhauser, Frank, Ragoschke, Andreas, Walter, Silke, Zimmer, Wilma   +10 more
core   +1 more source

Disentangling the effects of Alzheimer’s and small vessel disease on white matter fibre tracts

Brain : a journal of neurology, 2022
Alzheimer’s disease and cerebral small vessel disease are the two leading causes of cognitive decline and dementia and coexist in most memory clinic patients.
Anna Dewenter, Mina A. Jacob, Mengfei Cai, B. Gesierich, Paul Hager, Anna Kopczak, D. Biel, M. Ewers, A. Tuladhar, F. de Leeuw, M. Dichgans, N. Franzmeier, M. Duering   +12 more
semanticscholar   +1 more source

CADASIL: A monogenic condition causing stroke and subcortical vascular dementia [PDF]

, 2002
Mutations in Notch3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), an inherited small vessel disease leading to subcortical strokes and vascular dementia. The phenotypic presentation
Dichgans, Martin
core   +1 more source

Association of small vessel disease with tau pathology

Acta Neuropathologica, 2022
Emerging evidence suggests that small vessel disease (SVD) is a risk factor for clinical dementia and may contribute to AD neuropathological changes. Watershed brain regions are located at the most distal areas between arterial territories, making them ...
A. Kapasi, L. Yu, V. Petyuk, K. Arfanakis, D. Bennett, J. Schneider   +5 more
semanticscholar   +1 more source

Cerebral small vessel disease burden and cognitive and functional outcomes after stroke: A multicenter prospective cohort study

Alzheimer's & Dementia, 2022
It remains unknown whether the global small vessel disease (SVD) burden predicts post‐stroke outcomes.
Marios K. Georgakis, Rong Fang, M. Düring, F. Wollenweber, F. Bode, Sebastian Stösser, Christine Kindlein, Peter Hermann, T. Liman, C. Nolte, Lucia Kerti, B. Ikenberg, Kathleen Bernkopf, H. Poppert, W. Glanz, V. Perosa, D. Janowitz, Michael Wagner, K. Neumann, O. Speck, L. Dobisch, E. Düzel, B. Gesierich, Anna Dewenter, A. Spottke, K. Waegemann, M. Görtler, S. Wunderlich, M. Endres, I. Zerr, G. Petzold, M. Dichgans   +31 more
semanticscholar   +1 more source