Results 41 to 50 of about 1,168,068 (349)

Microglial activation and blood–brain barrier permeability in cerebral small vessel disease

Brain : a journal of neurology, 2021
See Edison (doi:10.1093/brain/awab149) for a scientific commentary on this article. Using advanced brain imaging techniques, Walsh et al. provide evidence of both neuroinflammation and increased blood-brain barrier permeability in patients with cerebral ...
J. Walsh, D. Tozer, H. Sari, Young T. Hong, A. Drazyk, Guy B. Williams, N. Shah, J. O'Brien, F. Aigbirhio, G. Rosenberg, T. Fryer, H. Markus   +11 more
semanticscholar   +1 more source

Frontal white matter lesions in Alzheimer’s disease are associated with both small vessel disease and AD-associated cortical pathology

Acta Neuropathologica, 2021
Cerebral white matter lesions (WML) encompass axonal loss and demyelination and are assumed to be associated with small vessel disease (SVD)-related ischaemia. However, our previous study in the parietal lobe white matter revealed that WML in Alzheimer’s
Kirsty E. McAleese, M. Miah, Sophie Graham, Georgina M. Hadfield, Lauren Walker, Mary Johnson, S. Colloby, Alan J. Thomas, C. DeCarli, D. Koss, J. Attems   +10 more
semanticscholar   +1 more source

Dawson's Fingers in Cerebral Small Vessel Disease

Frontiers in Neurology, 2020
To explore Dawson's fingers in cerebral small vessel disease (CSVD) and factors related to the development of Dawson's finger, we collected and analyzed clinical data of 65 patients with CSVD. We found a venous abnormality feature called Dawson's fingers
Aowei Lv, Zaiqiang Zhang, Ying Fu, Yaping Yan, Li Yang, Wenli Zhu   +5 more
doaj   +1 more source

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease

Nature Medicine, 2021
Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia.
Marie-Gabrielle Duperron, M. Knol, Quentin Le Grand, T. Evans, A. Mishra, A. Tsuchida, Gennady V. Roshchupkin, T. Konuma, D. Trégouët, J. Romero, S. Frenzel, M. Luciano, E. Hofer, M. Bourgey, Nicole D Dueker, P. Delgado, S. Hilal, Rick M. Tankard, Florian Dubost, Jean Shin, Y. Saba, N. Armstrong, Constance Bordes, M. Bastin, A. Beiser, H. Brodaty, R. Bülow, C. Carrera, Christopher P L H Chen, Ching-Yu Cheng, I. Deary, P. Gampawar, Jayanadra J Himali, Jiyang Jiang, T. Kawaguchi, Shuo Li, Mélissa Macalli, P. Marquis, Z. Morris, S. Muñoz Maniega, Susumu Miyamoto, M. Okawa, Matt Paradise, Pedram Parva, T. Rundek, M. Sargurupremraj, Sabrina Schilling, K. Setoh, O. Soukarieh, Y. Tabara, A. Teumer, A. Thalamuthu, J. Trollor, M. V. Valdés Hernández, Meike W. Vernooij, U. Völker, K. Wittfeld, T. Wong, M. Wright, Junyi Zhang, Wanting Zhao, Yi-cheng Zhu, H. Schmidt, P. Sachdev, W. Wen, Kazumichi Yoshida, A. Joutel, C. Satizabal, R. Sacco, G. Bourque, Quentin Le Grand, M. Lathrop, T. Paus, I. Férnandez-Cadenas, Qiong Yang, B. Mazoyer, P. Boutinaud, Y. Okada, H. Grabe, K. Mather, R. Schmidt, M. Joliot, M. Ikram, F. Matsuda, C. Tzourio, J. Wardlaw, S. Seshadri, H. Adams, S. Debette   +88 more
semanticscholar   +1 more source

Watching Small Vessel Disease Grow [PDF]

Circulation Research, 2018
Cerebrovascular disease is a major contributor to loss of brain health, a leading medical, societal, and financial issue worldwide.1 Although ischemic and hemorrhagic strokes are widely known end-organ effects, diseases of the cerebral circulation are important contributors to mild cognitive deficits, dementia, and an array of neurological and ...
openaire   +2 more sources

Cerebral Small Vessel Disease and Alzheimer's Disease: A Review

Frontiers in Neurology, 2020
Alzheimer's disease (AD) is the most common cause of dementia. Despite this, clear pathophysiology for AD has not been confirmed, and effective treatments are still not available.
Hae Won Kim, Jeongho Hong, Jae Cheon Jeon   +2 more
doaj   +1 more source

Pathophysiology of cerebral small vessel disease: a journey through recent discoveries

Journal of Clinical Investigation
Cerebral small vessel disease (cSVD) encompasses a heterogeneous group of age-related small vessel pathologies that affect multiple regions. Disease manifestations range from lesions incidentally detected on neuroimaging (white matter hyperintensities ...
Nicolas Dupré, Antoine Drieu, A. Joutel
semanticscholar   +1 more source

Small Vessel Disease: Neuropathology

International Psychogeriatrics, 2003
Diseases of small cerebral blood vessels are heterogeneous in etiology and manifestations. Lipohyalinosis, venous collagenosis, amyloid angiopathy, and CADASIL affect different populations of blood vessels. Large and small hemorrhages, lacunae, cortical microinfarcts, and leukoaraiosis are the most important consequences of the small vessel ...
openaire   +2 more sources

Total magnetic resonance imaging of cerebral small vessel disease burden predicts dysphagia in patients with a single recent small subcortical infarct

BMC Neurology, 2022
Background This study was performed to identify the association between the total magnetic resonance imaging burden of small vessel disease and the occurrence of post-stroke dysphagia in patients with a single recent small subcortical infarct (RSSI ...
Lulu Zhang, Xiang Tang, Yidan Li, Juehua Zhu, Dongxue Ding, Yun Zhou, Shanshan Diao, Yan Kong, Xiuying Cai, Ye Yao, Qi Fang   +10 more
doaj   +1 more source

Potential biomarkers of Alzheimer’s disease and cerebral small vessel disease

Frontiers in Molecular Neuroscience, 2022
BackgroundCerebral small vessel disease (CSVD) is associated with the pathogenesis of Alzheimer’s disease (AD). Effective treatments to alleviate AD are still not currently available.
Chun Zou, Xiaohua Huang, Yilong Zhang, Mika Pan, Jieqiong Xie, Liechun Chen, Youshi Meng, Donghua Zou, Donghua Zou, Jiefeng Luo   +9 more
doaj   +1 more source