Results 51 to 60 of about 1,093,638 (350)

Research progress of impaired cerebral hemodynamics in cerebral small vessel disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Cerebral hemodynamic damage is an important mechanism in the pathogenesis of arteriolosclerotic cerebral small vessel disease (CSVD). The hemodynamic damage of cerebral small vessel disease includes the changes of blood pressure variability (BPV ...
LIU Na, XUE Yang, TANG Jie, ZHANG Miao⁃yi, REN Xue , FU Jian⁃hui   +5 more
doaj   +1 more source

Homocysteine in Neurology: A Possible Contributing Factor to Small Vessel Disease

International Journal of Molecular Sciences, 2021
Homocysteine (Hcy) is a sulfur-containing amino acid generated during methionine metabolism, accumulation of which may be caused by genetic defects or the deficit of vitamin B12 and folate.
R. Moretti, M. Giuffré, P. Caruso, S. Gazzin, C. Tiribelli   +4 more
semanticscholar   +1 more source

Cerebral small vessel disease and cognitive impairment

Journal of Neurorestoratology, 2019
Cerebral small vessel disease (CSVD) is a pathophysiological process involving small arteries such as cerebellar arteries, arterioles, capillaries, and veinlets.
Lifang Meng, Jianhua Zhao, Junli Liu, Shaomin Li   +3 more
doaj   +1 more source

Cerebral small vessel disease genomics and its implications across the lifespan

Nature Communications, 2020
White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor.
M. Sargurupremraj, Hideaki Suzuki, X. Jian, C. Sarnowski, T. Evans, J. Bis, G. Eiriksdottir, S. Sakaue, N. Terzikhan, Mohamad Habes, Wei Zhao, N. Armstrong, E. Hofer, L. Yanek, S. Hagenaars, Rajan B. Kumar, E. B. van den Akker, Rebekah E. McWhirter, S. Trompet, A. Mishra, Y. Saba, C. Satizabal, G. Beaudet, L. Petit, A. Tsuchida, L. Zago, Sabrina Schilling, S. Sigurdsson, R. Gottesman, C. Lewis, N. Aggarwal, O. Lopez, Jennifer A. Smith, M. V. Valdés Hernández, J. van der Grond, M. Wright, M. Knol, M. Dörr, R. Thomson, Constance Bordes, Quentin Le Grand, Marie-Gabrielle Duperron, A. Smith, D. Knopman, P. Schreiner, Denis A. Evans, J. Rotter, A. Beiser, S. M. Maniega, M. Beekman, J. Trollor, D. Stott, M. Vernooij, K. Wittfeld, W. Niessen, A. Soumaré, E. Boerwinkle, S. Sidney, S. Turner, G. Davies, A. Thalamuthu, U. Völker, M. van Buchem, R. Bryan, J. Dupuis, M. Bastin, D. Ames, A. Teumer, P. Amouyel, J. Kwok, R. Bülow, I. Deary, P. Schofield, H. Brodaty, Jiyang Jiang, Y. Tabara, K. Setoh, S. Miyamoto, Kazumichi Yoshida, M. Nagata, Y. Kamatani, F. Matsuda, B. Psaty, D. Bennett, P. D. De Jager, T. Mosley, P. Sachdev, R. Schmidt, H. Warren, E. Evangelou, D. Trégouët, Philippe Mariza Saonli Claudine Jennifer A. Daniel I. Jean- Amouyel de Andrade Basu Berr Brody Chasman Dartigu, P. Amouyel, M. de Andrade, S. Basu, C. Berr, Jennifer A. Brody, D. Chasman, J. Dartigues, A. Folsom, M. Germain, H. D. de Haan, J. Heit, J. Houwing-Duitermaat, C. Kabrhel, P. Kraft, Grégoire Legal, S. Lindström, R. Monajemi, P. Morange, B. Psaty, P. Reitsma, Paul M Ridker, L. Rose, F. Rosendaal, N. Saut, Eline P. Slagboom, D. Smadja, N. Smith, P. Suchon, Weihong Tang, K. Taylor, D. Trégouët, C. Tzourio, M. D. de Visser, A. van Hylckama Vlieg, L. Weng, K. Wiggins, Padhraig Verneri Bendik S. Priit Tonu Tune H. Kai-How Ester Gormley Anttila Winsvold Palta Esko Pers Farh Cuen, P. Gormley, V. Anttila, B. Winsvold, P. Palta, T. Esko, T. Pers, Kai-How Farh, E. Cuenca-León, M. Muona, N. Furlotte, T. Kurth, A. Ingason, George Mcmahon, L. Ligthart, G. Terwindt, M. Kallela, T. Freilinger, C. Ran, S. Gordon, A. Stam, S. Steinberg, G. Borck, M. Koiranen, L. Quaye, H. Adams, T. Lehtimäki, Antti-Pekka Sarin, J. Wedenoja, D. Hinds, Julie E. Buring, M. Schürks, Paul M Ridker, Maria Gudlaug Hrafnsdottir, H. Stefánsson, S. Ring, J. Hottenga, B. Penninx, M. Färkkilä, V. Artto, M. Kaunisto, Salli Vepsäläinen, R. Malik, A. Heath, P. Madden, N. G. Martin, G. Montgomery, M. Kurki, M. Kals, R. Mägi, K. Pärn, E. Hämäläinen, Hailiang Huang, Andrea Byrnes, L. Franke, Jie Huang, E. Stergiakouli, Phil H. Lee, C. Sandor, C. Webber, Zameel M. Cader, Bertram Muller-Myhsok, Stefan Schreiber, T. Meitinger, J. Eriksson, V. Salomaa, K. Heikkilä, E. Loehrer, A. Uitterlinden, A. Hofman, Cornelia M. Van Duijn, L. Cherkas, L. Pedersen, A. Stubhaug, C. Nielsen, M. Männikkö, E. Mihailov, L. Milani, H. Göbel, A. Esserlind, Anne Francke Christensen, Thomas Folkmann Hansen, T. Werge, J. Kaprio, A. Aromaa, O. Raitakari, M. A. Ikram, T. Spector, M. Järvelin, A. Metspalu, C. Kubisch, D. Strachan, M. Ferrari, A. C. Belin, M. Dichgans, M. Wessman, A. M. van den Maagdenberg, J. Zwart, D. Boomsma, G. Davey Smith, K. Stefánsson, N. Eriksson, M. Daly, B. Neale, Jes Olesen, D. Chasman, D. Nyholt, A. Palotie, M. A. Ikram, W. Wen, C. DeCarli, V. Srikanth, J. Jukema, Eline P. Slagboom, S. Kardia, Y. Okada, B. Mazoyer, J. Wardlaw, P. Nyquist, K. Mather, H. Grabe, H. Schmidt, Cornelia M. Van Duijn, V. Gudnason, W. Longstreth, L. Launer, M. Lathrop, S. Seshadri, C. Tzourio, H. Adams, P. Matthews, M. Fornage, S. Debette   +260 more
semanticscholar   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

An unusual case of isolated symmetric bilateral peripheral artery disease of the radial artery of the index finger in systemic sclerosis: A case report and literature review

Journal of the Practice of Cardiovascular Sciences, 2022
We report an extremely rare and peculiar case of symmetric peripheral small-vessel disease involving only the radial artery of the index finger sparing major vessels in an 80-year-old female with systemic sclerosis (SSc). Our case is the first literature
Debasish Das, Anindya Banerjee, Abhinav Kumar, Shashikant Singh, Subhas Pramanik   +4 more
doaj   +1 more source

Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta‐analysis

Alzheimer's & Dementia, 2020
This paper is a proposal for an update on the characterization of cognitive impairments associated with sporadic cerebral small vessel disease (SVD). We pose a series of questions about the nature of SVD‐related cognitive impairments and provide answers ...
Olivia K. L. Hamilton, E. Backhouse, Esther Janssen, A. Jochems, Caragh Maher, Tuula E Ritakari, A. Stevenson, Lihua Xia, I. Deary, J. Wardlaw   +9 more
semanticscholar   +1 more source

Small Vessel Disease: Neuropathology

International Psychogeriatrics, 2003
Diseases of small cerebral blood vessels are heterogeneous in etiology and manifestations. Lipohyalinosis, venous collagenosis, amyloid angiopathy, and CADASIL affect different populations of blood vessels. Large and small hemorrhages, lacunae, cortical microinfarcts, and leukoaraiosis are the most important consequences of the small vessel ...
openaire   +3 more sources

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source