Results 81 to 90 of about 793,845 (297)

BCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs

Advanced Science, EarlyView.
Ng et al. show that the BCR::ABL1 kinase that drives the lymphoid leukemia Ph+B‐ALL modulates enhancer function by coopting signaling‐inducible transcription factors such as MYC, STAT5, and ETV5. BCR::ABL1 thereby promotes the transcriptional program driving and defining this leukemia and renders Ph+B‐ALL cells hypersensitive to enhancer‐inhibiting ...
Han Leng Ng, Trudy Lee Glaser, Jintao Zhu, Mark E. Robinson, Kadriye N. Cosgun, Valeriya Malysheva, Ozgen Deniz, Nicholas T. Crump, Kaiyue Helian, Andrew J. Innes, Richard Burt, Li Sun, George John, Haibin Zhou, Atsunori Kaneshige, Longchuan Bai, Shaomeng Wang, Mikhail Spivakov, Markus Müschen, Niklas Feldhahn   +19 more
wiley   +1 more source

Pan2‐Pan3 Complex‐Mediated Deadenylation Enforces mRNA Quality Control for Infection of the Rice Blast Fungus

Advanced Science, EarlyView.
Discovery that deadenylation, rather than transcription, acts as the rate‐limiting step for developmental timing in a plant pathogen. Evidence that P‐body integrity and mRNA decay are mechanistically coupled to rapid cellular differentiation under environmental stress. Identification of Pan2‐Pan3 as a pathogen‐specific “meta‐virulence factor” absent in
Ziwei Lv, Junting Feng, Shenxian Zhou, Zhiguang Qu, Jun Peng, Xiao‐Lin Chen, Deng Chen   +6 more
wiley   +1 more source

vEMRec: High‐Resolution Volume Electron Microscopy Reconstruction Based on Structure‐Preserving and High‐Fidelity 3D Alignment

Advanced Science, EarlyView.
vEMRec is a frequency‐adaptive computational framework for three‐dimensional alignment in volume electron microscopy. It integrates feature‐based rigid alignment with Gaussian filter‐guided elastic registration to correct rigid misalignments and nonlinear distortions while preserving structural fidelity.
Zhenbang Zhang, Hongjia Li, Zhongjun Yang, Zhiqiang Xu, Duanchen Sun, Xin Gao, Fa Zhang, Renmin Han   +7 more
wiley   +1 more source

The impact of the brics’ universities on internationalization of smart cities technologies [PDF]

, 2016
Within the past decade, the increased use of technology in all sectors of society has created a push for cities to integrate the latest and greatest into their city development economically, socially and politically.
Bentsion, V.
core  

Real‐Time and High‐Resolution NIR‐II‐L Imaging of Netrin‐1‐Mediated Neurovascular Coupling Driven by Dose‐Dependent Electroacupuncture

Advanced Science, EarlyView.
Disrupted neurovascular coupling contributes to ovarian dysfunction in polycystic ovary syndrome. Using near‑infrared II long‑wavelength imaging, this study visualizes how electroacupuncture dynamically regulates ovarian blood vessels in vivo. Immediate and cumulative stimulation elicit distinct vascular responses via a Netrin‐1 dependent mechanism ...
Yicong Wang, Zi‐Han Chen, Jiajia Li, Wei Hu, Ying Cao, Yu Wang, Xiaoyu Tong, Wenhan Lu, Yuze Yang, Yuehao Wang, Yan Xiao, Wenhao Gao, Yuning Chen, Yuyan Hou, Fan Zhang, Yi Feng   +15 more
wiley   +1 more source

Machine Learning-Enhanced 3D GIS Urban Noise Mapping with Multi-Modal Factors

ISPRS International Journal of Geo-Information
Geographic Information System (GIS)-based noise management is crucial in urban environments as it provides precise spatial analysis, helping to identify noise hotspots and optimize noise control measures.
Jianping Pan, Yuzhe He, Wei Ma, Shengwang An, Lu Li, Dan Huang, Dunxin Jia   +6 more
doaj   +1 more source

MONICA in Hamburg: Towards Large-Scale IoT Deployments in a Smart City

, 2018
Modern cities and metropolitan areas all over the world face new management challenges in the 21st century primarily due to increasing demands on living standards by the urban population.
Fischer, Michael, Meiling, Sebastian, Purnomo, Dorothea, Schmidt, Thomas C., Shiraishi, Julia-Ann   +4 more
core   +1 more source

Inhibiting cGAS‐STING to Preserve Mitochondrial–Nuclear Communication and Stemness in Young Tendon Stem Cells: A Hydrogel Strategy against Age‐Related Tendinopathy

Advanced Science, EarlyView.
A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang, Weiyong Song, Heng Yin, Yi Wang, Yi Zou, Yuling Li, Yue Luo, Chao Xiang, Xiaoqin Liu, Yan Xiong, Yong Wang, Ke Jiang   +11 more
wiley   +1 more source

Smart cities, creative Cities of smart citizens?

, 2019
Discussies over de ‘Smart City’ draaien vaak om technologieën die destad efficiënter moeten maken. Naast deze ‘control-room’-visie staantwee minder bekende benaderingen: ‘Smart Citizens’ zet technologiein om burgers meer zeggenschap te geven, terwijl de ‘Creative City’ destad beziet als ‘living lab’.
de Waal, Martijn, Majoor, Stan
openaire   +2 more sources

Evolutionary Trend Analysis of Agricultural Non-Point Source Pollution Load in Chongqing Based on Land Use Simulation

Agronomy
Analysis of the relationship between future land use change and agricultural non-point source pollution (ANPSP) evolution is vital to promoting sustainable regional development.
Kangwen Zhu, Yan Zhang, Xiaosong Tian, Dongjie Guan, Sheng Zhang, Yong He, Lilei Zhou   +6 more
doaj   +1 more source