Results 161 to 170 of about 10,513 (271)

Multi‐omics profiling of chronic immune‐mediated skin diseases: SKINERGY protocol and strategic evaluation

Journal of the European Academy of Dermatology and Venereology, EarlyView.
The SKINERGY study will investigate six immune‐mediated inflammatory skin diseases through a nationwide collaboration across all Dutch university medical centres. Involving 720 patients and 120 healthy volunteers, it is aimed at generating a high‐quality dataset to identify biomarkers that enable personalized treatment strategies and improved disease ...
N. G. Koster, J. M. P. A. van den Reek, E. M. G. J. de Jong, S. van Beugen, A. I. M. van Laarhoven, I. Haeck, M. de Bruin‐Weller, M. L. Schuttelaar, B. Horvath, A. Gostyński, A. Knulst, M. H. Vermeer, L. Nguyen, L. Gerbens, P. Spuls, M. A. Middelkamp‐Hup, V. Exadaktylos, T. Niemeyer‐van der Kolk, A. R. Schrader, A. M. Sluijmers, J. Versteeg, B. W. M. Arents, I. van Ee, J. L. A. G. van der Zon, M. de Leeuw, T. de Leeuw, P. van den Broek, C. Berkhof, D. Vellinga, S. Weidinger, S. Dubrac, Y. Li, M. van Steensel, M. Marchetti‐Deschmann, M. Maurer, H. van der Zee, J. Damman, D. J. Hijnen, F. Wijk, M. M. B. Seyger, H. Röckmann, D. M. W. Balak, M. B. A. van Doorn, R. Rissmann, The Next Generation ImmunoDermatology (NGID) consortium, Rob Vreeken, Eva Cuypers, Boudewijn Lelieveldt, Abdoel El Ghalbzouri, Hanna Niehues, Ellen van den Bogaard, Tom Ederveen, Els van der Pool, Nanda Olde, Debra Trampe, Ellen Stijl‐’t Hart, Lisanne Wezendonk, Johan Westerhuis, Huma Shehwana, Joerg Schreiber, Jeremy Bost, Mie Bech Lukassen, Jimmy Bakker, Juliette Simons, Fauve van den Berge, Colin Spence, Elise Beljaards, Anastasiia Myronenko, Mariona Oliver   +68 more
wiley   +1 more source

Human multi-tissue transcriptomics identifies galectin-1 and follistatin-like 1 as exerkines with distinct transcript-to-serum coupling after exercise. [PDF]

J Physiol
Song J, Cho ES, Kwon YR, Park JS, Nam JS, Kim Y.   +5 more
europepmc   +1 more source

The changing landscape of training in microscopy facilities: Reflections on seven decades of research user support at the University of Sydney

Journal of Microscopy, EarlyView.
Abstract This thematic contribution highlights the critical role of established professional training regimes in microscopy and microanalysis in supporting high‐quality research. As microscopy technologies continue to evolve in complexity, the risk of mishandling and data misinterpretation by inexperienced researchers increases significantly.
Eleanor Kable, Matthew Foley, Vijay Bhatia, Filip Braet   +3 more
wiley   +1 more source

Feeding Laboratory Mice: Comparing a Standard Versus a Purified Diet – Marked Effects on Digestive Physiology

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Diet composition and processing have a major impact on its utilisation by the animal, as is known from farm and pet animal species. This includes effects on energy and nutrient digestibility, the intermediary metabolism, and the intestinal microbiome, with all the resulting impacts. For laboratory animals, data is scarce on influencing factors
L. F. Böswald, A. Zeyner, M. M. Santo, M. Wensch‐Dorendorf, A. Sünder, B. Popper, W. Siegert   +6 more
wiley   +1 more source

Change in skeletal muscle mass during systemic cancer treatment: a systematic review and meta-analysis. [PDF]

Acta Oncol
Svendsen L, Jensen S, Hansen S, Sørensen V, Johansen C, Suetta C, Pappot H, Simonsen C, Hermann Tang L, Oksbjerg Dalton S, Ammitzbøll G, Skjødt Rafn B.   +11 more
europepmc   +1 more source

Iterative Genome Engineering Platform Enables Efficient Sucrose Biosynthesis From CO2 in Photosynthetic Synechococcus elongatus UTEX 2973

Plant Biotechnology Journal, EarlyView.
ABSTRACT The single crossover occurring via homologous recombination is a common phenomenon existing among microbes like Escherichia coli, Bacillus subtilis, Vibrio natriegens, Gluconobacter oxydans and most cyanobacteria species, threatening the stability of engineered strains and challenging iterative genetic engineering. Among them, we take the fast‐
Shubin Li, Tao Sun, Dailin Liu, Tong Zhang, Lei Chen, Weiwen Zhang   +5 more
wiley   +1 more source

Directed Evolution of Plant‐Associated Bacteria Enhances Plant Holobiont Stress Tolerance

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant stress responses are shaped by both the plant genome and its associated microbial communities, which together form the plant holobiont. Given the rapid adaptive potential of plant‐associated microbes, we hypothesised that directed evolution under selective pressure can accelerate the development of holobiont‐level stress tolerance ...
Mohammadhossein Ravanbakhsh, Wu Xiong
wiley   +1 more source

Experimental models of cerebral small vessel disease: Physiological constraints, translational challenges and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of cerebral small vessel disease (cSVD) pathophysiology and current modelling challenges. Left: clinical burden and key unresolved research questions. Right: neurovascular unit (NVU) architecture highlighting sites of cSVD pathology across arterioles, capillaries and venules, including interactions between endothelial ...
Sophie Beaumont, Tanya Singh, Luana Campos Soares, Mootaz M. Salman   +3 more
wiley   +1 more source

Coevolution of NK and Tumor Cell States Along Multiple Myeloma Progression from Precursor Conditions. [PDF]

Int J Mol Sci
Aquilina C, Romano A, Corsale AM, Biondo M, Speciale M, Tofacchi E, Di Simone M, Gigliotta E, Dieli C, Avellone C, Toscano A, Camarda L, Romano A, Cambria D, Giavaresi G, Raimondi L, Neri A, Campana S, Caccamo N, Dieli F, Siragusa S, Meraviglia S, Botta C.   +22 more
europepmc   +1 more source

Photobiomodulation restores blood–brain barrier integrity after hypoxia via endothelial von Willebrand factor modulation in a humanised tricellular transwell model

The Journal of Physiology, EarlyView.
Abstract figure legend Photobiomodulation restores blood–brain barrier (BBB) integrity following hypoxic stress. A multicellular human BBB model comprising brain microvascular endothelial cells, astrocytes and pericytes was established in a transwell system and subjected to acute hypoxia.
Mirriam Domocos, Denis E. Bragin, Nagesh C. Shanbhag, Luise Schlotterose, Mootaz M. Salman   +4 more
wiley   +1 more source