Results 121 to 130 of about 55,907 (261)

Laboratory Biology, Immature and Adult Morphology of Trichopria drosophilae (Perkins) (Hymenoptera: Diapriidae), Parasitoids of Drosophila Flies

Entomologia Experimentalis et Applicata, EarlyView.
This study investigates the laboratory biology and morphology of the parasitoid Trichopria drosophilae, which targets Drosophila flies, including the invasive Drosophila suzukii. Key findings include a detailed description of the parasitoid's egg, three larval instars, and pupal stage, as well as unique behaviors such as siblicide and encapsulation in ...
Alex Gumovsky, Jana Collatz, Lesia Tymochko, Lars Krogmann   +3 more
wiley   +1 more source

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, EarlyView.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

The FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz, Daniel Pérez‐Calixto, Jorge Carretero‐Ortega, Aida Gabriela Guzman‐López, Diana Cristina Pinto‐Dueñas, Mariana Hernández‐Juárez, Alejandra Jiménez‐Escobar, Adriana Rodríguez‐Hernández, Beatriz Díaz‐Bello, Nathalia Serna‐Márquez, Miguel Ángel Peña‐Rico, Laura Gómez‐Romero, Francisco Gabriel Vázquez‐Cuevas, Genaro Vázquez‐Victorio   +13 more
wiley   +1 more source

Extracellular vesicles efficiently deliver survival motor neuron protein to cells in culture

Scientific Reports
Spinal Muscular Atrophy (SMA) is a genetic neuromuscular disorder caused by homozygous mutation or deletion of the survival motor neuron 1 (SMN1) gene, leading to a low quantity of SMN protein in cells.
Charlotte A. René, Robin J. Parks
doaj   +1 more source

The Illness Narratives of Children and Young People With Spinal Muscular Atrophy: A Scoping Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim(s) This review seeks to explore the illness narratives of children and young people focusing on their healthcare trajectories; the right to health; and the kind of stories told about them. Design This scoping review adopts a narrative approach to analyse how the illness experience of Spinal Muscular Atrophy is represented in the literature,
Marcela González‐Agüero, Constanza Quezada, Valentina Turén, Josefa Camelio, Martina De Filippi, Caroline Bradbury‐Jones, Julie Taylor   +6 more
wiley   +1 more source

Outcome and cost‐effectiveness of transdiagnostic cognitive behavioral therapy compared with management as usual for youth with common mental health problems: Long‐term results from the Mind‐My‐Mind randomized trial

Journal of Child Psychology and Psychiatry, EarlyView.
Background Credible long‐term outcomes from randomized trials evaluating the effectiveness and cost‐effectiveness of preventive programs for mental health problems are needed. We compared long‐term effects of the Mind My Mind (MMM) transdiagnostic cognitive behavioral therapy (CBT) program to management as usual (MAU). Methods The study was a pragmatic,
Ditte Vassard, Martin Køster Rimvall, Rasmus Trap Wolf, Robin Christensen, Sabrina M. Nielsen, Kerstin Jessica Plessen, Frank Verhulst, Niels Bilenberg, Per Hove Thomsen, Mikael Thastum, Simon‐Peter Neumer, Anne Katrine Pagsberg, Wendy K. Silverman, Christoph U. Correll, Pia Jeppesen   +14 more
wiley   +1 more source

Emergency Departments Leading the Transformation of Alzheimer's and Dementia Care: Emergency Care Redesign

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Over 50% of persons living with dementia (PLWD) and their care partners (dyads) visit the emergency department (ED) every year. In the ED, healthcare professionals face complex challenges managing acute issues and symptoms of Alzheimer's disease and Alzheimer's disease–related dementias without provider training or in‐ED structures to ensure a
Afshana Hoque, Allison Cuthel, Corita R. Grudzen, Manish N. Shah, Abraham A. Brody, Jori E. Fleisher, Jennifer DiMascio‐Donohue, Katelyn McLain, Lin T. Tun, Julia Levine, Keith S. Goldfeld, Joshua Chodosh, ED‐LEAD Investigators, Lauren Abbate, Rebecca Anthopolos, Alicia Arbaje, Fernanda Bellolio, Jonathan Berkowitz, Andrea Blome, Erik Jonathan Blutinger, Justin Kenneth Brooten, Reed Caldwell, Christopher Caspers, Nathaniel Chin, Edward Cisek, Valerie Cotter, Jeremy Thomas Cushman, Dan David, Allison L. Ducharme‐Smith, Scott Dresden, Mary Ellen Dupont, Marie Carmelle Elie, Andra Farcas, Bucky Ferozan, Nicholas Genes, Cameron Gettel, Andrea Gilmore‐Bykovski, Elizabeth Goldberg, Scott Goldberg, Satheesh Gunaga, Heather Heaton, Courtney Jones, Maura Kennedy, Timmy Li, Joseph Miller, Brian Mittman, Kei Ouchi, Brian W Patterson, Jennifer Portz, Alex Quinones, Suzanne Ryer, Ashley Shreves, Michelle Simpson, Silas Smith, Payal Sud, Joe Suyama, Scotty Thomas, Victoria Vaughan Dickson, Ian Wittman, Nancy Wood   +59 more
wiley   +1 more source

The distinct functional brain network and its association with psychotic symptom severity in men with methamphetamine-associated psychosis

BMC Psychiatry
Background Individuals using methamphetamine (METH) may experience psychosis, which usually requires aggressive treatment. Studies of the neural correlates of METH-associated psychosis (MAP) have focused predominantly on the default mode network (DMN ...
Zhen-An Hwang, Ai-Ling Hsu, Chia-Wei Li, Changwei W. Wu, Chun-Hsin Chen, Wing P. Chan, Ming-Chyi Huang   +6 more
doaj   +1 more source

Bridging the Gap Between the ED and Home: The Community Paramedic‐Led Transitions Intervention for Persons Living With Dementia

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT More than 6 million persons living with dementia (PLWD) in the United States rely on the emergency department (ED) for unscheduled care, with up to half discharged home after treatment. The ED‐to‐home transition poses significant challenges for PLWD and their care partners (referred to as “dyads”), contributing to high rates of ED revisits and
Meghan Jenkins Morales, Stephanie Ricketts, Corita R. Grudzen, Abraham A. Brody, Joshua Chodosh, Keith Goldfeld, Manish N. Shah, ED‐LEAD Investigators, Lauren Abbate, Rebecca Anthopolos, Alicia Arbaje, Fernanda Bellolio, Jonathan Berkowitz, Andrea Blome, Erik Jonathan Blutinger, Justin Kenneth Brooten, Reed Caldwell, Christopher Caspers, Nathaniel Chin, Edward Cisek, Valerie Cotter, Jeremy Thomas Cushman, Dan David, Allison L. Ducharme‐Smith, Scott Dresden, Mary Ellen Dupont, Marie Carmelle Elie, Andra Farcas, Bucky Ferozan, Jori Fleisher, Nicholas Genes, Cameron Gettel, Andrea Gilmore‐Bykovski, Scott Goldberg, Elizabeth Goldberg, Satheesh Gunaga, Heather Heaton, Courtney Jones, Maura Kennedy, Timmy Li, Joseph Miller, Brian Mittman, Kei Ouchi, Brian W. Patterson, Jennifer Portz, Alex Quinones, Ashley Shreves, Michelle Simpson, Silas Smith, Payal Sud, Joe Suyama, Scotty Thomas, Victoria Vaughan Dickson, Ian Wittman, Nancy Wood   +54 more
wiley   +1 more source

Variation in trabecular bone microarchitecture across rhesus macaque (Macaca mulatta) load‐bearing joints

Journal of Anatomy, EarlyView.
Aging of bone density (BV/TV) is regional: Forelimb [left] elements gain bone sporadically (orange) but hind limb elements [right] lose bone globally (blue). Abstract Globally, human population structure is quickly trending older, increasing the prevalence and systemic burden of age‐related skeletal disorders such as osteoporosis.
Cassandra M. Turcotte, Aditi Raghunath, Timothy M. Ryan, Lily J. D. DeMars, Erin Siracusa, Sam K. Patterson, Cayo Biobank Research Unit, Michael L. Platt, Lauren J. N. Brent, Noah Snyder‐Mackler, Samuel E. Bauman, Michael J. Montague, Melween I. Martinez, Scott A. Williams, Susan C. Antón, James P. Higham, Sharon Kuo   +16 more
wiley   +1 more source