Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching. [PDF]
PLoS ONE, 2012 Bindarit, a selective inhibitor of monocyte chemotactic proteins (MCPs) synthesis, reduces neointimal formation in animal models of vascular injury and recently has been shown to inhibit in-stent late loss in a placebo-controlled phase II clinical trial.
Marcella Maddaluno +11 more
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Orai store-operated Ca2+ entry channels modulate urethral smooth muscle contractility [PDF]
ChannelsIn the European Union, urinary incontinence (UI) affects 45% of adults during their lifetime, representing a major clinical and socio-economic burden. Failure of urethral smooth muscle (USM) to contract normally (hypo or hypercontractility) contributes ...
Bernard T. Drumm, Neha Gupta
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Three-dimensional-mapping of smooth muscle morphogenesis in the vertebrate gastrointestinal tract [PDF]
Scientific ReportsGastrointestinal (GI) motility depends on smooth muscle contractions to propel contents through the digestive tract. GI muscle is organized into two perpendicular layers: the inner circular smooth muscle (CSM) and the outer longitudinal smooth muscle ...
Salomé Ruiz Demoulin +4 more
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HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype [PDF]
, 2019 Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or descending ...
Rajeev Malhotra +49 more
openalex +4 more sources
The extracellular signal-regulated kinase (ERK) pathway: a potential therapeutic target in hypertension [PDF]
Journal of Experimental Pharmacology, 2012 Richard E RobertsSchool of Biomedical Sciences, University of Nottingham, Nottingham, United KingdomAbstract: Hypertension is a risk factor for myocardial infarction, stroke, renal failure, heart failure, and peripheral vascular disease.
Roberts RE
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Physiological Reports, 2022 Penile detumescence is maintained by tonic contraction of corpus cavernosum smooth muscle cells (CCSMC), but the underlying mechanisms have not been fully elucidated.
Xin Rui Lim +4 more
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Defining smooth muscle cells and smooth muscle injury [PDF]
Journal of Clinical Investigation, 2005 For 3 decades, terms such as synthetic phenotype and contractile phenotype have been used to imply the existence of a specific mechanism for smooth muscle cell (SMC) responses to injury. In this issue of the JCI, Hendrix et al. offer a far more precise approach to examining the mechanisms of SMC responses to injury, focused not on general changes in ...
William M, Mahoney, Stephen M, Schwartz
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Sepsis downregulates aortic Notch signaling to produce vascular hyporeactivity in mice
Scientific Reports, 2022 Inhibition of Notch signaling in macrophages is known to reduce inflammation, however, its role in regulating vascular hyporeactivity in sepsis is unknown. Thus we aimed to evaluate the effect of sepsis on vascular Notch signaling.
Vandana Singh +8 more
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Role of smooth muscle progenitor cells in vascular mechanical injury and repair
Medicine in Novel Technology and Devices, 2022 Smooth muscle progenitor cells are precursor cells that express both smooth muscle cell and stem cell markers, and can differentiate into smooth muscle cells under specific condition.
Zhu-feng Dong +7 more
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Characterization of Cecal Smooth Muscle Contraction in Laying Hens
Veterinary Sciences, 2021 The ceca play an important role in the physiology of the gastrointestinal tract in chickens. Nevertheless, there is a gap of knowledge regarding the functionality of the ceca in poultry, especially with respect to physiological cecal smooth muscle ...
Katrin Röhm +3 more
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