Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching. [PDF]
Bindarit, a selective inhibitor of monocyte chemotactic proteins (MCPs) synthesis, reduces neointimal formation in animal models of vascular injury and recently has been shown to inhibit in-stent late loss in a placebo-controlled phase II clinical trial.
Marcella Maddaluno +11 more
doaj +2 more sources
Protein changes associated with embryonic stem cell differentiation to vascular smooth muscle cells [PDF]
PhDEmbryonic stem (ES) cells can differentiate into many different cell lines, including vascular smooth muscle cells (SMCs). The aim of this project is to characterize protein changes during this differentiation process.
Yin, Xiaoke
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Changes of smooth muscle contractile filaments in small bowel atresia [PDF]
AIM: To investigate morphological changes of intestinal smooth muscle contractile fibres in small bowel atresia patients. METHODS: Resected small bowel specimens from small bowel atresia patients (n = 12) were divided into three sections (proximal ...
Rolle, Udo +4 more
core +1 more source
A serine proteinase with kallikrein-like activity (LV-Ka) has been purified to homogeneity from bushmaster snake (Lachesis muta muta) venom. Physicochemical studies indicated that LV-Ka is a single chain glycoprotein with a molecular mass (Mr) of 33 kDa ...
Maria L.D. Weinberg +6 more
doaj +1 more source
Notch2 and Notch3 function together to regulate vascular smooth muscle development. [PDF]
Notch signaling has been implicated in the regulation of smooth muscle differentiation, but the precise role of Notch receptors is ill defined. Although Notch3 receptor expression is high in smooth muscle, Notch3 mutant mice are viable and display only ...
Qingqing Wang +3 more
doaj +1 more source
Cell cultures of human ciliary muscle: growth, ultrastructural and immunocytochemical characteristics [PDF]
Primary ciliary muscle cell cultures derived from human donors (16-91 years) were established and characterized by comparing them with ciliary muscle in tissue sections using immunocytochemical and ultrastructural methods.
Baur, A. +7 more
core +1 more source
Calcium Handling in Airway Smooth Muscle: Mechanisms and Therapeutic Implications
Calcium plays a central role in the activation of many cellular processes, including the most relevant end-point in airway smooth muscle physiology: contraction.
Luke J Janssen
doaj +1 more source
We previously reported the relationship between α1-adrenoceptor-mediated contraction and phosphorylation of 20-kDa myosin light chain (LC20) in de-endothelialized rat caudal arterial smooth muscle at room temperature (Mita M, Walsh MP. Biochem J.
Mitsuo Mita +2 more
doaj +1 more source
Endothelin-Induced Sarcoplasmic Reticulum Calcium Depletion Waves in Vascular Smooth Muscle Cells [PDF]
Agonist-stimulated waves of elevated cytoplasmic Ca2+ concentration ([Ca2+]i ) regulate blood vessel tone and vasomotion in vascular smooth muscle. Previous studies employing cytoplasmic Ca2+ indicators revealed that these Ca2+ waves were generated by a ...
Cornelis van Breemen +7 more
core +1 more source
Opiate Modulation of Gastrointestinal Motility and the Actions of Trimebutine
Trimebutine is an opiate ligand that interacts with the μ, σ and κ receptor subclasses with approximately equal affinity. Since opiate receptors are widely distributed in the gut, and because opiate receptor subtypes may be involved in excitatory or ...
Stephen M Collins, Edwin E Daniel
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