Results 261 to 270 of about 945,943 (347)

SREBP1-mediated lipogenesis promotes dedifferentiation and senescence of vascular smooth muscle cells through epigenetic remodeling. [PDF]

Nat Commun
Li B, Zhou K, Yin A, Liu Y, Wang X, Cui Y, Liu F, Liu Q, Zheng H, Mu Z, Chen K, Wu Y, Chang Y, Bao J.   +13 more
europepmc   +1 more source

Tumor‐Derived Interleukin 35 Promotes Fibrosis in the Tumor Microenvironment of Pancreatic Cancer by Activating Pancreatic Stellate Cells

Advanced Science, EarlyView.
This study demonstrates that tumor‐derived IL‐35 promotes pancreatic cancer fibrosis by indirectly activating pancreatic stellate cells through IGFBP2/IGF‐1R/PI3K‐Akt and Tsp‐1/TGF‐β pathways. IL‐35 blockade reduces stromal fibrosis, restores chemosensitivity, and synergizes with gemcitabine‐based regimens, highlighting IL‐35 as a promising therapeutic
Hui Li, Huizhi Sun, Jing Liu, Yan Wu, Lin Wei, Jianming Li, Yudong Yuan, Peng Xie, Chao Xu, Guolu Luo, Yuqi Guan, Yukuan Feng, Antao Chang, Jihui Hao, Chongbiao Huang   +14 more
wiley   +1 more source

Cholesterol induced-mitochondrial calcium dysregulation facilitates atherosclerosis by promoting lipid accumulation in vascular smooth muscle cells. [PDF]

Mol Biomed
Zhang Z, Yang F, Wang W, Cao Q, Zhang L, Zhang Y, Ma D, Zhang X, Wen J, Zheng B.   +9 more
europepmc   +1 more source

Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins

Advanced Science, EarlyView.
As newly emerged optogenetic tools, potassium channelrhodopsins (KCRs) can drift from inhibition to activation during illumination as K⁺ selectivity declines. It is shown that both the absolute K⁺/Na⁺ permeability ratio and its stability over time govern this drift, identify KCR1‐C29D as a reliably inhibitory variant, and outline design principles for ...
Xiao Duan, Chong Zhang, Stanislav Ott, Zhiyi Zhang, Christiane Ruse, Sven Dannhäuser, Robert Jacobi, Nadine Ehmann, Divya Sachidanandan, Georg Nagel, Manfred Heckmann, Robert J. Kittel, Alexander Gottschalk, Adam Claridge‐Chang, Shiqiang Gao   +14 more
wiley   +1 more source

Mechanical stretch regulates inflammatory signaling in human smooth muscle cells

Jensen LF, Markov A, Alonso-Herranz L, Thomsen EA, Mikkelsen JG, Bentzon JF, Albarrán-Juárez J.   +6 more
europepmc   +1 more source

Smooth muscle relaxants for intrauterine device placement: A systematic review. [PDF]

Contraception
Snyder EM, Krishna G, Zapata LB, Nguyen AT, Whiteman MK, Curtis KM.   +5 more
europepmc   +1 more source

Bifurcate Regulation of Hematopoietic Homeostasis and Bone Osteogenesis by VHL‐HIF2α‐Controlled Adipocyte Function

Advanced Science, EarlyView.
The VHL‐HIF2α (VHL is Von Hippel‐Lindau) axis in adipocytes differentially regulates hematopoiesis and bone formation through stem cell factor (SCF) and chemerin, respectively. This hypoxia‐responsive pathway in adipocytes establishes a systemic signaling network with HSCs and MSCs to maintain tissue homeostasis, revealing a targetable axis for ...
Qian Li, Jia Li, Anshu Tang, Cong Li, Chao Zhang, Congcong Zhang, Yun‐Cai Liu   +6 more
wiley   +1 more source

Thrombospondin-4 regulates apoptosis of vascular smooth muscle cells after artery transplanted into vein. [PDF]

Sci Rep
Xu F, Jia X, Chai S, Fan Y.
europepmc   +1 more source

Edible Pneumatic Battery for Sustained and Repeated Robot Actuation

Advanced Science, EarlyView.
This work presents an edible energy source and valve system to power soft, pneumatically driven edible robots. A chemical reaction between sodium bicarbonate and citric acid generates carbon dioxide gas, and a pressure‐triggered edible valve enables self‐repetitive motion of the edible actuator.
Bokeon Kwak, Shuhang Zhang, Alexander Keller, Qiukai Qi, Jonathan Rossiter, Dario Floreano   +5 more
wiley   +1 more source

MAPK14 converges on key transcriptional machinery to promote vascular smooth muscle cell degeneration in abdominal aortic aneurysm. [PDF]

Signal Transduct Target Ther
Wu X, Wang C, Ishimwe N, Zhang W, Doja J, Shan S, Ge C, Sun Y, Zhao J, Castillo M, Sotonyi P, Gyurok G, Csanyi G, Bryant WB, Dong K, Chen Y, Vazquez-Padron R, Miano JM, Long X.   +18 more
europepmc   +1 more source