Results 321 to 330 of about 2,783,257 (365)

NFAT Regulation in Smooth Muscle

Trends in Cardiovascular Medicine, 2003
First identified in activated T cells, the calcium (Ca2+)-dependent transcription factor, nuclear factor of activated T cells (NFAT), has since been shown to play a role in nonimmune cells, including cells of the cardiovascular system. In arterial smooth muscle, the diverse array of calcium-signaling modalities, the functional interplay between smooth ...
Nelson, Mark, Hill-Eubanks, David C., Gomez, Maria F., Stevenson, Andra S., Nelson, Mark T.   +4 more
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Evidence that unphosphorylated smooth muscle myosin supports smooth muscle contraction

Biochemical and Biophysical Research Communications, 1991
Unphosphorylated smooth muscle myosin filaments do not disassemble in MgATP, provided that the solution is supplemented either by 25% serum albumin or by 6% polyethylene glycol 6000. These filaments are able to support actomyosin retraction but their ATPase activity is not activated by tropomyosin-decorated F-actin.
Enrico Grazi, Giorgio Trombetta
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Tracheal Smooth Muscle

Clinics in Chest Medicine, 1986
Contraction of tracheal smooth muscle requires the binding of Ca2+ to calmodulin, which then binds to and activates MLCK. The Ca2+-calmodulin-MLCK complex catalyzes the phosphorylation of myosin, which causes contraction by stimulating actin-activated Mg2+-ATPase activity of myosin.
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Halothane Increases Smooth Muscle Protein Phosphatase in Airway Smooth Muscle

Anesthesiology, 2001
Background Halothane relaxes airway smooth muscle, in part, by decreasing the force produced for a given intracellular [Ca(2+)] (i.e., Ca(2+) sensitivity) during muscarinic stimulation, an effect produced by a decrease in regulatory myosin light-chain (rMLC) phosphorylation.
Keith A. Jones, William J. Perkins, Motohiko Hanazaki, David O. Warner   +3 more
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[7] Smooth muscle mitochondria

1979
Publisher Summary In contrast with other tissues, such as liver and heart, where the mitochondria are particularly abundant, the bulk of smooth muscle tissue consists of myofibrils and connective tissue with relatively few mitochondria. This and the fact that large amounts of smooth muscle are difficult to obtain routinely have resulted in only a few
B Sloane, Antonio Scarpa, A P Somlyo, J Valliéres   +3 more
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Airway Smooth Muscle in Asthma

Annual Review of Pathology: Mechanisms of Disease, 2004
Airway smooth muscle plays a multifaceted role in the pathogenesis of asthma. We review the current understanding of the contribution of airway myocytes to airway inflammation, airway wall remodeling, and airflow obstruction in this prevalent disease syndrome. Together, these roles make airway smooth muscle an attractive target for asthma therapy.
Julian Solway, Blanca Camoretti-Mercado, Melanie Brown, Marc B. Hershenson   +3 more
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Ca2+ Movements in Smooth Muscle

Chest, 1980
We describe the Ca2+ movements in smooth muscle cells at rest and during activation and relaxation as deduced from transplasmalemmal Ca2+ fluxes and contractile respnses. The general picture which emerges is: the resting cell has a [Ca2+]cyt below 10(-7) M and large gradients are poised across both the cell membrane and intracellular membranes ...
R. Loutzenhiser, Kaushik D. Meisheri, P. Aaronson, C. van Breemen   +3 more
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Calcium sparks in smooth muscle

American Journal of Physiology-Cell Physiology, 2000
Local intracellular Ca2+transients, termed Ca2+sparks, are caused by the coordinated opening of a cluster of ryanodine-sensitive Ca2+release channels in the sarcoplasmic reticulum of smooth muscle cells. Ca2+sparks are activated by Ca2+entry through dihydropyridine-sensitive voltage-dependent Ca2+channels, although the precise mechanisms of ...
Nelson, MT., Jaggar, J, Porter, V, Lederer, W   +3 more
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SMOOTH MUSCLE ELECTROLYTES

Canadian Journal of Biochemistry and Physiology, 1958
The sodium, potassium, chloride, and water concentrations have been analyzed in relatively pure smooth muscles of electrophysiological interest and compared to similar analyses of other muscle types. The smooth muscles analyzed included isolated longitudinal myometrium from the uteri of various species and the taenia coli from guinea pigs and rabbits.
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Electrophysiology of Smooth Muscle

Physiological Reviews, 1963
Mollie E. Holman, C. L. Prosser, Geoffrey Burnstock   +2 more
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