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EPAC in Vascular Smooth Muscle Cells [PDF]
International Journal of Molecular Sciences, 2020 Vascular smooth muscle cells (VSMCs) are major components of blood vessels. They regulate physiological functions, such as vascular tone and blood flow. Under pathological conditions, VSMCs undergo a remodeling process known as phenotypic switching. During this process, VSMCs lose their contractility and acquire a synthetic phenotype, where they over ...
Nadine Wehbe +9 more
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Smoothelin in Vascular Smooth Muscle Cells [PDF]
Trends in Cardiovascular Medicine, 2007 Smoothelin-A and -B have only been found in fully differentiated contractile smooth muscle cells. They are increasingly used to monitor the smooth muscle cell differentiation process to a contractile or synthetic phenotype. Vascular-specific smoothelin-B is the first smooth muscle cell marker that disappears when vascular tissues are compromised, for ...
van Eys, G.J.J.M. +2 more
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Vascular Smooth Muscle Cells [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2016 Decades of work have shown that vascular smooth muscle cell (SMC) phenotypes are controlled by cues received from the local environment.1–3 When nestled into a cage of cross-linked collagen and elastin of its own making,4 medial SMCs exhibit a fully differentiated phenotype conferred by the transcriptional activity of myocardin and serum response ...
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Vascular Smooth Muscle Updated [PDF]
Circulation Research, 1973 • This brief review of the rapidly developing research on vascular smooth muscle presents the state of the art as I see it from within my own frame of reference. For a more objective, detailed insight into the workings of vascular smooth muscle, several substantial reviews and compendiums may be read (1-7).
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Smooth muscle cells and vascular diseases [PDF]
Cardiovascular Research, 2012 Vascular smooth muscle cells (VSMCs) are the stromal cells of the vascular wall, and, due to their myosin/actin interactions, they are also responsible for arterial contractile tonus and regulating blood pressure and flow in relation to specific metabolic demands.
Jean-Baptiste, Michel +2 more
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Vascular smooth muscle contraction in hypertension [PDF]
Cardiovascular Research, 2018 Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia, and chronic kidney disease. Pathophysiological mechanisms contributing to the development of hypertension include increased vascular resistance, determined in large part by reduced vascular diameter due to ...
Touyz, Rhian M. +6 more
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URETHANE AND CONTRACTION OF VASCULAR SMOOTH MUSCLE [PDF]
British Journal of Pharmacology, 1979 In vitro studies were undertaken on rat aortic strips and portal vein segments in order to determine whether or not the anaesthetic, urethane, can exert direct actions on vascular smooth muscle. Urethane was found to inhibit development of spontaneous mechanical activity.
B M, Altura, J, Weinberg
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Calcium Channels in Vascular Smooth Muscle [PDF]
, 2017 Calcium (Ca2+) plays a central role in excitation, contraction, transcription, and proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca2+ concentration ([Ca2+]i) is crucial for proper physiological VSM function.
D, Ghosh +6 more
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THICK FILAMENTS IN VASCULAR SMOOTH MUSCLE [PDF]
The Journal of Cell Biology, 1971 Two sets of myofilaments were demonstrated after incubation of strips of rabbit portal-anterior mesenteric vein under moderate stretch in a physiological salt solution. Thick filaments had a mean diameter of 18 nm and reached a maximum length of 1.4 µm with a mean length of 0.61 µm.
C E, Devine, A P, Somlyo
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Guidance Molecules in Vascular Smooth Muscle [PDF]
Frontiers in Physiology, 2018 Several highly conserved families of guidance molecules, including ephrins, Semaphorins, Netrins, and Slits, play conserved and distinct roles in tissue remodeling during tissue patterning and disease pathogenesis. Primarily, these guidance molecules function as either secreted or surface-bound ligands that interact with their receptors to activate a ...
Alexandra Christine Finney +3 more
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