Results 271 to 280 of about 6,895,201 (344)

PRMT5 inhibition suppresses the PI3K/AKT pathway to attenuate vascular smooth muscle cell pathological phenotype in intracranial aneurysm. [PDF]

Front Neurol
Kang J, Li W, Tian X, Feng W, Yao X, Wei F, Chen H, Tong J, Chen E.   +8 more
europepmc   +1 more source

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

MiR-199a-3p deficiency induced by STAT3 activation drives smooth muscle cell phenotypic switching in pulmonary arterial hypertension. [PDF]

Noncoding RNA Res
He WX, Huang YJ, Ai TH, Huang SQ, You XH, Wu H, Song XW.   +6 more
europepmc   +1 more source

GLS1 governs vascular smooth muscle cell phenotypic switching and aortic dissection via glutamate metabolism. [PDF]

JCI Insight
Xie W, Ning C, Lu C, Wang D, Zhao S, Song T, Cao H.   +6 more
europepmc   +1 more source

Differential Tissue‐Coupled Powering for Battery‐Free Injectable Electroceuticals

Advanced Science, EarlyView.
A thread‐like injectable neural stimulator is powered through differential tissue‐coupled powering (DTCP), which harvests RF‐frequency tissue potentials with an elongated receiver while preserving a injectable cross‐section. The system integrates an ASIC, stimulation electrodes, and a portable transmitter, enabling wireless peripheral nerve stimulation,
Han Wu, Sultan Mahmud, Mali Halac, Asif Iftekhar Omi, Domenica Sofia Baez Rodas, Jeremiasz Dados, Chaojun Cheng, Anyu Jiang, Cameron Wallace, Anvi Singh, Erin Patrick, Baibhab Chatterjee, Shriya Srinivasan, Adam Khalifa   +13 more
wiley   +1 more source

Correction to: Estriol attenuates visceral adiposity and pulmonary artery smooth muscle cell proliferation via ERα-mediated signalling. [PDF]

Eur Heart J Open
europepmc   +1 more source

<i>ECH1</i>-Deficiency-Mediated Polyunsaturated Fatty Acid Accumulation Promotes Vascular Smooth Muscle Cell Ferroptosis and Chronic-Kidney-Disease-Associated Plaque Vulnerability. [PDF]

Research (Wash D C)
Bi X, Zhou J, Liu L, Chen Z, Liang B, Tian S, Xiong J, Lan Q, Lv L, Li Y, Xiao T, He T, Zhang J, Nie L, Zhao J.   +14 more
europepmc   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Smooth Muscle Cell-Derived Exosomal miR-30a-5p as a Novel Therapeutic Strategy for Erectile Dysfunction in Diabetes Mellitus. [PDF]

Andrology
Song J, Hu P, Wang J, Xu W, Cui K, Wang T, Liu J, Ruan Y.   +7 more
europepmc   +1 more source

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

Advanced Science, EarlyView.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang, Qiyue Zhang, Yueyang Qiu, Haocheng Suo, Zengqian Liu, Bing Bai, Qiang Wang, Qing Zhou   +7 more
wiley   +1 more source