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Leptin and Vascular Smooth Muscle Cells
Current Pharmaceutical Design, 2014This review concerns the influence of leptin on vascular smooth muscle cells (VSMC). VSMC express different isoforms of the leptin receptor (Ob-R) able to activate a wide range of intracellular signalling pathways, mediating many relevant biological actions.
Mariella, Trovati +5 more
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Electrical parameters of smooth muscle cells
American Journal of Physiology-Legacy Content, 1963Spikes in circular intestinal muscle fibers show volume-conductor shapes and conduct faster in low resistance medium than in air. Longitudinal space constant is 1.0 mm (20 cell lengths if 50% overlap); transverse space constant is 0.27 mm or 50 cell widths.
T, NAGAI, C L, PROSSER
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The good smooth muscle cells in atherosclerosis
Current Atherosclerosis Reports, 2000The formation of a fibrous cap made up of intimal smooth muscle cells and connective tissue is part of an attempt by the vessel wall to encapsulate the toxic products accumulating in the necrotic core of atherosclerotic lesions, and should be viewed as a beneficial healing response.
S M, Schwartz +2 more
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Airway smooth muscle: An immunomodulatory cell
Journal of Allergy and Clinical Immunology, 2002Asthma is characterized in part by reversible airflow obstruction, hyperresponsiveness, and inflammation. Chronic obstructive pulmonary disease, which includes chronic bronchitis, emphysema, and possibly bronchiectasis, is defined as predominantly irreversible airflow obstruction associated with abnormal airway inflammation.
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Smooth Musculature. Smooth Muscle Cells
1985This three-dimensional figure illustrates the plane of contact between the longitudinally and circularly coursing muscle layers of the tunica muscularis of the intestine. In addition to the nuclei (1) and endoplasm (2) with its organelles, the muscle cells can be seen to contain longitudinally oriented microfilaments (3), dense bodies (4), a peripheral
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Migration of Airway Smooth Muscle Cells
American Journal of Respiratory Cell and Molecular Biology, 2003Airway smooth muscle cells (ASMCs) have more than a single “function.” In addition to an obvious contractile function that regulates rapid changes in airway caliber, these cells have both a proliferative function that leads to hyperplasia and hypertrophy of smooth muscle in persistent asthma, and a secretory function that contributes to the ...
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The cytoskeleton of the vertebrate smooth muscle cell
Acta Physiologica Scandinavica, 1998Smooth muscle cells possess a structural lattice composed of two primary parts: the ‘cytoskeleton’ that pervades the cytoplasm and the ‘membrane skeleton’ that provides anchorage for the cytoskeleton and contractile apparatus at the cell surface. The cytoskeleton contains two major components: first, a complement of actin filaments that links the ...
J V, Small, M, Gimona
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Smooth muscle cell growth factors
Progress in Growth Factor Research, 1991While the roles of the platelet-derived growth factors (PDGFs) in vascular smooth muscle cells (SMCs) continue to be elucidated, these cells, especially in their activated 'synthetic' state, have also been found to express, and proliferate in response to, many of the other families of polypeptide growth factors, such as the fibroblast growth factors ...
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Cytokines and smooth muscle cells in atherosclerosis
Cardiovascular Research, 1993For several years it has been recognised that the common denominator for many of the well known risk factors for cardiovascular disease is that they all may give rise to chronic inflammatory reactions in vascular tissues. New tools made available through rapid progress in the fields of immunology and molecular biology have made it possible to reach a ...
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Molecular regulation of vascular smooth muscle cell differentiation in development and disease.
Physiological Reviews, 2004G. Owens, Meena S. Kumar, B. Wamhoff
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