Results 11 to 20 of about 382,633 (219)

Regulation of human airway smooth muscle cell migration and relevance to asthma

Respiratory Research, 2017
Airway remodelling is an important feature of asthma pathogenesis. A key structural change inherent in airway remodelling is increased airway smooth muscle mass.
Brittany Salter, Cara Pray, Katherine Radford, James G. Martin, Parameswaran Nair   +4 more
doaj   +1 more source

Mechanism of progesterone promoting uterine smooth muscle contraction through RhoA/ROCK signaling pathway

陆军军医大学学报, 2022
Objective To investigate the mechanism of progesterone affecting the contractions of uterine smooth muscle through RhoA/ROCK signaling pathway. Methods The tissues of uterine smooth muscle were collected from 5 cases in labor and another 5 of non-labor ...
YAN Xiaoli, CHEN Cheng, WANG Dan, CHANG Qing   +3 more
doaj   +1 more source

Differentiation of Murine Bone Marrow-Derived Smooth Muscle Progenitor Cells Is Regulated by PDGF-BB and Collagen. [PDF]

PLoS ONE, 2016
Smooth muscle cells (SMCs) are key regulators of vascular disease and circulating smooth muscle progenitor cells may play important roles in vascular repair or remodelling.
Clifford Lin, Yifan Yuan, David W Courtman   +2 more
doaj   +1 more source

Implanted Mouse Bone Marrow-Derived Cells Reconstruct Layered Smooth Muscle Structures in Injured Urinary Bladders

Cell Transplantation, 2008
This study is a preliminary investigation to determine if bone marrow-derived cells, when implanted into freeze-injured urinary bladders, differentiate into smooth muscle cells and reconstruct smooth muscle layers.
Tetsuya Imamura, Yoshiaki Kinebuchi, Osamu Ishizuka, Satoshi Seki, Yasuhiko Igawa, Osamu Nishizawa   +5 more
doaj   +1 more source

Lack of α8 integrin leads to morphological changes in renal mesangial cells, but not in vascular smooth muscle cells

BMC Cell Biology, 2010
Background Extracellular matrix receptors of the integrin family are known to regulate cell adhesion, shape and functions. The α8 integrin chain is expressed in glomerular mesangial cells and in vascular smooth muscle cells.
Hilgers Karl F, Goppelt-Struebe Margarete, Özcan Zehra, Zürn Christina, Fahlbusch Fabian, Jahn Angelika, Volkert Gudrun, Marek Ines, Rascher Wolfgang, Hartner Andrea   +9 more
doaj   +1 more source

Silencing of NOTCH3 Signaling in Meniscus Smooth Muscle Cells Inhibits Fibrosis and Exacerbates Degeneration in a HEYL‐Dependent Manner

Advanced Science, 2023
The mechanisms of meniscus fibrosis and novel ways to enhance fibrosis is unclear. This work reveals human meniscus fibrosis initiated at E24 weeks. Smooth muscle cell cluster is identified in embryonic meniscus, and the combined analysis with previous ...
Hao Sun, Fangzhou Liu, Zhencan Lin, Zongrui Jiang, Xingzhao Wen, Jie Xu, Zhiqi Zhang, Ruofan Ma   +7 more
doaj   +1 more source

Fibronectin matrix polymerization regulates smooth muscle cell phenotype through a Rac1 dependent mechanism. [PDF]

PLoS ONE, 2014
Smooth muscle cells are maintained in a differentiated state in the vessel wall, but can be modulated to a synthetic phenotype following injury. Smooth muscle phenotypic modulation is thought to play an important role in the pathology of vascular ...
Feng Shi, Xiaochun Long, Allison Hendershot, Joseph M Miano, Jane Sottile   +4 more
doaj   +1 more source

Pathologic bladder microenvironment attenuates smooth muscle differentiation of skin derived precursor cells: implications for tissue regeneration. [PDF]

PLoS ONE, 2013
Smooth muscle cell containing organs (bladder, heart, blood vessels) are damaged by a variety of pathological conditions necessitating surgery or organ replacement.
Cornelia Tolg, Alya Ahsan, Shaalee Dworski, Tyler Kirwan, Jeffery Yu, Karen Aitken, Darius Jehan Bägli   +6 more
doaj   +1 more source

Cyclic Mechanical Stretch Induced Smooth Muscle Cell Changes in Cerebral Aneurysm Progress by Reducing Collagen Type IV and Collagen Type VI Levels

Cellular Physiology and Biochemistry, 2018
Background/Aims: Cerebral aneurysm growth is characterized by continuous structural weakness of local smooth muscle cells, though the mechanism is unclear.
Peixi Liu, Yaying Song, Yingjie Zhou, Yingjun Liu, Tianming Qiu, Qingzhu An, Jianping Song, Peiliang Li, Yuan Shi, Sichen Li, Kai Quan, Guo-Yuan Yang, Wei Zhu   +12 more
doaj   +1 more source

The Atypical Cadherin FAT1 Limits Mitochondrial Respiration and Proliferation of Vascular Smooth Muscle Cells

Frontiers in Cardiovascular Medicine, 2022
Smooth muscle cells contribute to cardiovascular disease, the leading cause of death worldwide. The capacity of these cells to undergo phenotypic switching in mature arteries of the systemic circulation underlies their pathogenic role in atherosclerosis ...
Dario F. Riascos-Bernal, Dario F. Riascos-Bernal, Alishba Maira, Nicholas E. S. Sibinga, Nicholas E. S. Sibinga   +4 more
doaj   +1 more source