Results 111 to 120 of about 1,270,469 (233)

Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy

Advanced Science, EarlyView.
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou, Ruihua Ji, Qinglu Zang, Mingkang Wang, Lingling Zhou, Yingliang Wei, Di Yang, Yue Wu, Hongxu Zhu, Jianrong Wu, Xiaojun Cai, Wenxian Du, Junjie Cheng, An Zeng, Yuehua Li   +14 more
wiley   +1 more source

An Extended Hydro-Mechanical Coupling Model Based on Smoothed Particle Hydrodynamics for Simulating Crack Propagation in Rocks under Hydraulic and Compressive Loads. [PDF]

Materials (Basel), 2023
Mu D, Mu D, Tang A, Qu H, Wang J.
europepmc   +1 more source

Molecular‐Level Pore Engineering for Precise Separation via Active Solvent‐Mediated Interfacial Polymerization

Advanced Science, EarlyView.
We demonstrate that microemulsion solvents can actively template molecular‐level pores within selective layer during interfacial polymerization. By creating localized quasi‐homogeneous polymerization zones, the membrane achieved a 7.1‐fold enhancement in water permeance with increased selectivity.
Feng Li, R. M. G. Rajapakse, Yuxin Mou, Deyin Hou, Min Yang   +4 more
wiley   +1 more source

RESEARCH AREAS OF THE UNESCO CHAIR ON NEW INFORMATION TECHNOLOGIES. PART 2. MESHLESS METHODS

Вестник Кемеровского государственного университета, 2013
This paper provides an overview of the main results of solving the nonlinear free-boundary hydrodynamic problems with meshless methods. Special attention is paid to computations using the Natural Element Methods and Smoothed Particle Hydrodynamics.
K. E. Afanasyev, S. N. Karabtsev, R. S. Makarchuk, T. S. Rein   +3 more
doaj  

Fluid-Structure Interaction Analyses of Biological Systems Using Smoothed-Particle Hydrodynamics. [PDF]

Biology (Basel), 2021
Toma M, Chan-Akeley R, Arias J, Kurgansky GD, Mao W.   +4 more
europepmc   +1 more source

Balancing resolution and response in computational steering with simulation trails [PDF]

, 2009
Computational steering provides many opportunities to gain additional insight into a numerical simulation, for example by facilitating what-if experimentation, detection of unstable situations and termination of uninteresting runs.
Walker, Rick, Miao, Jingqi, Kenny, Peter G.   +2 more
core  

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Three-dimensional smoothed-particle hydrodynamics simulation of deformation characteristics in slope failure

, 2016
This paper presents the development, validation and application of a smoothed-particle hydrodynamics model for three-dimensional (3D) simulation of the evolution of large deformation failure in geomaterials.
石传奇, 安翼, 刘青泉, 吴强, An, Y (reprint author), Chinese Acad Sci, Inst Mech, Key Lab Mech Fluid Solid Coupling Syst, Beijing, Peoples R China.   +4 more
core   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

Consistent Thermo-Capillarity and Thermal Boundary Conditions for Single-Phase Smoothed Particle Hydrodynamics. [PDF]

Materials (Basel), 2021
Bierwisch C.
europepmc   +1 more source