Results 271 to 280 of about 29,268 (294)

The highly expressed <i>GOLPH3</i> in colorectal cancer cells activates smoothened to drive glycolysis and promote cancer cell growth and radiotherapy resistance. [PDF]

J Gastrointest Oncol
Zhu K, Fan J, Cai H, Zhou C, Gong Z, Li Z, Yu J.   +6 more
europepmc   +1 more source

Hedgehog pathway activity downstream of Smoothened is regulated specifically by basal ciliary PKA. [PDF]

Cell Mol Biol Lett
Zhang H, Chen S, Huang Z, Ben J, Wei Y, Chen G, Wu C, Xie H, W Ingham P, Zhao Z.   +9 more
europepmc   +1 more source

Resistance to SMO Inhibitors in Advanced Basal Cell Carcinoma: A Case Highlighting the Role of Molecular Tumor Profiling. [PDF]

Int J Mol Sci
Papaccio F, Marrapodi R, Eibenschutz L, D'Arino A, Caputo S, Marini A, Scano S, Presaghi A, Cota C, Melucci E, Scalera S, Migliano E, Maugeri-Saccà M, Frascione P, Bellei B.   +14 more
europepmc   +1 more source

In vitro differentiation of the hypothalamic KNDy neuron, a master regulator for reproduction, from mouse embryonic stem cells. [PDF]

Reprod Biol Endocrinol
Miyake N, Suga H, Osuka S, Seki T, Sonehara R, Muraoka A, Nakamura T, Bayasula, Miwata T, Soen M, Sakakibara M, Go S, Hasegawa S, Inoue N, Uenoyama Y, Tsukamura H, Arima H, Kajiyama H.   +17 more
europepmc   +1 more source

A Potent Antagonist of Smoothened in Hedgehog Signaling for Epilepsy

International Journal of Molecular Sciences, 2022
Epilepsy is one of the common encephalopathies caused by sudden abnormal discharges of neurons in the brain. About 30% of patients with epilepsy are insensitive and refractory to existing antiseizure medications.
Ru Liu, Jianping Wu, Wei Chen
exaly   +2 more sources

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Hedgehog signalling in bone and osteoarthritis: the role of Smoothened and cholesterol

The FEBS Journal, 2022
Hedgehog signalling is essential for development, crucial for normal anatomical arrangement and activated during tissue damage repair. Dysregulation of hedgehog signalling is associated with cancer, developmental disorders and other diseases including ...
A. Smith, Elín Sóley Sigurbjörnsdóttir, E. Steingrímsson, Sara Sigurbjörnsdóttir   +3 more
semanticscholar   +1 more source

Smoothened is a therapeutic target for reducing glutamate toxicity in ischemic stroke

Science Translational Medicine, 2021
Description Activation of SHH pathway contributes to glutamate toxicity, and inhibition of SMO reduces ischemic brain damage in mice and monkeys. A smooth-ened approach for ischemia One of the consequences of brain ischemia is the release of glutamate ...
Yuqing Wang, Shanshan Lu, Yifei Chen, Liang Li, Xia Li, Zhongwei Qu, Junbo Huang, Liu Fan, Chao Yuan, Nan Song, Jun Zhang, Wendong Xu, Shenglian Yang, Yizheng Wang   +13 more
semanticscholar   +1 more source

Discovery of NVP‐LEQ506, a Second‐Generation Inhibitor of Smoothened

ChemMedChem, 2013
Inhibition of the Hedgehog (Hh) pathway targeting the Smoothened receptor has proven therapeutic benefit for the treatment of Hh-dependent cancers. Lead optimization provided a novel type of Smoothened inhibitor based on a pyridazine core resulting in ...
Stefan Peukert, Karen Miller-Moslin, Ribo Guo   +2 more
exaly   +2 more sources

The interplay of Patched, Smoothened and cholesterol in Hedgehog signaling.

Current Opinion in Cell Biology, 2019
The Hedgehog (HH) pathway plays a pivotal role in regulating a diverse array of events from embryonic tissue patterning to adult organ self-renewal. Aberrant activation of the pathway is linked to carcinogenesis. Key factors in the HH pathway include the
Ao Hu, B. Song
semanticscholar   +1 more source