Results 261 to 270 of about 22,572 (280)

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

ACS Medicinal Chemistry Letters, 2010
Tove Tuntland, Xu Wu, Fangxian Sun
exaly  

Cholesterol Interaction Sites on the Transmembrane Domain of the Hedgehog Signal Transducer and Class F G Protein-Coupled Receptor Smoothened

Structure, 2019
Mark S.P. Sansom, Rajat Rohatgi, Christian Siebold   +2 more
exaly  

Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened

ACS Medicinal Chemistry Letters, 2012
Christopher S Jones, Qifang Li, Andrei Shavnya   +2 more
exaly  

Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines

Bioorganic and Medicinal Chemistry Letters, 2010
Qiuping Ye, Guifen Xu, Dustin L McMinn
exaly  

Vertebrate smoothened proteins

1998
DE SAUVAGE FREDERIC J, ROSENTHAL ARNON, STONE DONNA M   +2 more
openaire   +4 more sources

-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists

Bioorganic and Medicinal Chemistry Letters, 2011
Christian Steinkühler, Alberto Bresciani, Edith Monteagudo   +2 more
exaly  

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling

Molecular Cell, 2017
Lei Yin, Catherine Cl Wong, Wen-Wei Qiu
exaly  

Design, synthesis, and structure–activity-relationship of phenyl imidazoles as potent Smoothened antagonists

Bioorganic and Medicinal Chemistry Letters, 2012
Tove Tuntland, Nathan P Englund, Wenqi Gao   +2 more
exaly  

Smoothened Correlators

2008
openaire   +1 more source

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors

Cancers, 2016
Shadi A Qasem, Richard L Carpenter, Hui-Wen Lo   +2 more
exaly