Results 241 to 250 of about 22,572 (280)
Cilia-Associated Oxysterols Activate Smoothened [PDF]
Molecular Cell, 2018 Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but how Smoothened accumulates in cilia and is activated is incompletely understood. Here, we identify cilia-associated oxysterols that promote Smoothened accumulation in
Alexis Leigh Krup +2 more
exaly +10 more sources
A Potent Antagonist of Smoothened in Hedgehog Signaling for Epilepsy
International Journal of Molecular Sciences, 2022 Epilepsy is one of the common encephalopathies caused by sudden abnormal discharges of neurons in the brain. About 30% of patients with epilepsy are insensitive and refractory to existing antiseizure medications.
Jianping Wu, Ru Liu, Wei Chen
exaly +2 more sources
The Role of Smoothened in Cancer [PDF]
International Journal of Molecular Sciences, 2020 Smoothened (SMO) belongs to the Hedgehog (HH) signaling pathway, which regulates cell growth, migration, invasion and stem cells in cancer. The HH signaling pathway includes both canonical and noncanonical pathways. The canonical HH pathway functions through major HH molecules such as HH ligands, PTCH, SMO and GLI, whereas the noncanonical HH pathway ...
Kuo-Shyang Jeng +2 more
exaly +3 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance The Hedgehog pathway is critical in development and disease, but how cells respond to the secreted Hedgehog signal remains mysterious.
Benjamin R. Myers +2 more
exaly +2 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Smoothening the path for hedgehogs
Trends in Cell Biology, 1996Studies of the HEDGEHOG signalling pathway in Drosophila have revealed a functional link between two genes, cubitus interruptus and patched, whose human homologues are, respectively, a proto-oncogene and a tumour suppressor. While the former has been implicated as a transcription factor, controversy has surrounded the function of the transmembrane ...
M, van den Heuvel, P W, Ingham
openaire +2 more sources
Discovery of NVP-LEQ506, a Second-Generation Inhibitor of Smoothened
ChemMedChem, 2013 Inhibition of the Hedgehog (Hh) pathway targeting the Smoothened receptor has proven therapeutic benefit for the treatment of Hh-dependent cancers. Lead optimization provided a novel type of Smoothened inhibitor based on a pyridazine core resulting in ...
Silvia Buonamici +2 more
exaly +2 more sources
Smoothened antagonists for hair inhibition
Bioorganic and Medicinal Chemistry Letters, 2010A series of aminomethylpyrazoles were prepared and evaluated using cell-based Smoothened beta-lactamase reporter assay and Smoothened binding assay. Potent Smoothened antagonists 10k and 10l were found to inhibit hair growth in vivo in the C3H/HeN mouse hair growth model.
Manju Swaroop +2 more
exaly +3 more sources
Characterization of Smoothened Phosphorylation and Activation
2021The GPCR-family protein Smoothened (Smo) is an obligatory signal transducer of the Hedgehog (Hh) signaling pathway. Binding of Hh to its receptor Patched (Ptc) alleviates Ptc-mediated inhibition of Smo, allowing Smo to activate the Cubitus interruptus (Ci)/Gli family of zinc finger transcription factors.
Jianhang, Jia +3 more
openaire +2 more sources
1990
The smoothening process, in the form needed in the construction of Neron models, is presented in Sections 3.1 to 3.4. After we have explained the main assertion, we discuss the technique of blowing-up which is basic for obtaining smoothenings. The actual proof of the existence of smoothenings is carried out in Sections 3.3 and 3.4.
Siegfried Bosch +2 more
openaire +1 more source
The smoothening process, in the form needed in the construction of Neron models, is presented in Sections 3.1 to 3.4. After we have explained the main assertion, we discuss the technique of blowing-up which is basic for obtaining smoothenings. The actual proof of the existence of smoothenings is carried out in Sections 3.3 and 3.4.
Siegfried Bosch +2 more
openaire +1 more source
Targeting of Smoothened for therapeutic gain
Trends in Pharmacological Sciences, 2014The Smoothened (Smo) receptor is a key transducer of the Hedgehog (Hh) signaling pathway, which plays a critical role in tissue maintenance and repair. Recent studies have highlighted the therapeutic value of Smo antagonists for treating Hh-linked cancers.
Ruat, Martial +3 more
openaire +2 more sources