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Quantum Smoothening of ‘Classical Anomaly’
Letters in Mathematical Physics, 1997zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Smoothened Inhibitors in Cancer
2015Smoothened (Smo) inhibitors are under intense development for the treatment of cancers linked to abnormal Hedgehog (Hh) signaling. The first inhibitor (vismodegib) was introduced in clinics for basal cell carcinoma and medulloblastomas associated with activating mutations of Hh signaling. In contrast, disappointing data are reported for cancers related
Martial Ruat, Lucile Hoch
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Sterols Ligands for Smoothened
Science's STKE, 2006In the absence of Sonic hedgehog (Shh), Patched (Ptc, a receptor for Shh) inhibits signaling by Smoothened (Smo). In certain cancers, including medulloblastoma, the Shh pathway is activated, for example, by loss-of-function mutations in Ptc. However, defective Shh signaling is also associated with disease.
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A Partner for Smoothened in Cilia
Science Signaling, 2012A protein implicated in inherited ciliopathies recruits Smoothened to a ciliary microdomain and is required for Hedgehog signaling.
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Structural Basis of Smoothened Activation in Hedgehog Signaling
Cell, 2018Jing Liu, Adrian Salic, Andrew Kruse
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Smoothened Regulation: A Tale of Two Signals
Trends in Pharmacological Sciences, 2016Stacey K Ogden, Suresh Marada
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