Results 201 to 210 of about 41,949 (243)

Smoothened Agonist Treatment Mitigates Vasogenic Edema, Neuroinflammation, and Neurological Dysfunction Following Traumatic Brain Injury in Mice. [PDF]

FASEB J
Michinaga S, Takahashi K, Ogawa Y, Mizuguchi H, Hishinuma S.   +4 more
europepmc   +1 more source

Impact of substrate choice on human osteoclast differentiation and secretome: Implications for targeted therapeutic development. [PDF]

PLoS One
D'Amélio F, Vigerelli H, Araldi RP, da Costa Neves A, Prieto-da-Silva ÁRB, Pimenta D, Kerkis I.   +6 more
europepmc   +1 more source

Pancreatic cancer-associated myofibroblasts: a review. [PDF]

Int J Biol Sci
Banacki M, Inkielewicz-Stepniak I.
europepmc   +1 more source

Advancing Medulloblastoma Treatment: Molecular Mechanisms, Drug Repurposing, and Precision Therapies. [PDF]

Mol Diagn Ther
Abdel-Rasol MA, El-Sayed WM.
europepmc   +1 more source

Genetic Insight into Gorlin-Goltz Syndrome.

Indian J Dermatol
Madhu M.
europepmc   +1 more source

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Smoothened antagonists for hair inhibition

Bioorganic & Medicinal Chemistry Letters, 2010
A series of aminomethylpyrazoles were prepared and evaluated using cell-based Smoothened beta-lactamase reporter assay and Smoothened binding assay. Potent Smoothened antagonists 10k and 10l were found to inhibit hair growth in vivo in the C3H/HeN mouse hair growth model.
Jie Jack, Li, Veerabahu, Shanmugasundaram, Satya, Reddy, Laura L, Fleischer, Zenquan, Wang, Yvonne, Smith, William G, Harter, Wen-Song, Yue, Manju, Swaroop, Ling, Li, Christy Xiaodong, Ji, Danielle, Dettling, Bella, Osak, Laura R, Fitzgerald, Robert, Conradi   +14 more
openaire   +2 more sources

Smoothening the path for hedgehogs

Trends in Cell Biology, 1996
Studies of the HEDGEHOG signalling pathway in Drosophila have revealed a functional link between two genes, cubitus interruptus and patched, whose human homologues are, respectively, a proto-oncogene and a tumour suppressor. While the former has been implicated as a transcription factor, controversy has surrounded the function of the transmembrane ...
M, van den Heuvel, P W, Ingham
openaire   +2 more sources

Characterization of Smoothened Phosphorylation and Activation

2021
The GPCR-family protein Smoothened (Smo) is an obligatory signal transducer of the Hedgehog (Hh) signaling pathway. Binding of Hh to its receptor Patched (Ptc) alleviates Ptc-mediated inhibition of Smo, allowing Smo to activate the Cubitus interruptus (Ci)/Gli family of zinc finger transcription factors.
Jianhang, Jia, Yuhong, Han, Yong Suk, Cho, Jin, Jiang   +3 more
openaire   +2 more sources