Results 211 to 220 of about 41,949 (243)

The Smoothening Process

1990
The smoothening process, in the form needed in the construction of Neron models, is presented in Sections 3.1 to 3.4. After we have explained the main assertion, we discuss the technique of blowing-up which is basic for obtaining smoothenings. The actual proof of the existence of smoothenings is carried out in Sections 3.3 and 3.4.
Siegfried Bosch, Werner Lütkebohmert, Michel Raynaud   +2 more
openaire   +1 more source

Quantum Smoothening of ‘Classical Anomaly’

Letters in Mathematical Physics, 1997
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openaire   +2 more sources

Targeting of Smoothened for therapeutic gain

Trends in Pharmacological Sciences, 2014
The Smoothened (Smo) receptor is a key transducer of the Hedgehog (Hh) signaling pathway, which plays a critical role in tissue maintenance and repair. Recent studies have highlighted the therapeutic value of Smo antagonists for treating Hh-linked cancers.
Martial, Ruat, Lucile, Hoch, Hélène, Faure, Didier, Rognan   +3 more
openaire   +2 more sources

Sterols Ligands for Smoothened

Science's STKE, 2006
In the absence of Sonic hedgehog (Shh), Patched (Ptc, a receptor for Shh) inhibits signaling by Smoothened (Smo). In certain cancers, including medulloblastoma, the Shh pathway is activated, for example, by loss-of-function mutations in Ptc. However, defective Shh signaling is also associated with disease.
openaire   +1 more source

Smoothened Inhibitors in Cancer

2015
Smoothened (Smo) inhibitors are under intense development for the treatment of cancers linked to abnormal Hedgehog (Hh) signaling. The first inhibitor (vismodegib) was introduced in clinics for basal cell carcinoma and medulloblastomas associated with activating mutations of Hh signaling. In contrast, disappointing data are reported for cancers related
Martial Ruat, Lucile Hoch
openaire   +1 more source

Smoothened

2011
openaire   +2 more sources

smoothen, v.

2023
openaire   +1 more source

Structural Basis of Smoothened Activation in Hedgehog Signaling

Cell, 2018
Sanduo Zheng, Bradley M Wierbowski, Youngchang Kim   +2 more
exaly  

Smoothened boundaries

Trends in Genetics, 1998
openaire   +1 more source

Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists

Cancer Cell, 2013
James Kim, Blake T Aftab, Emily M King
exaly