Results 71 to 80 of about 889,338 (324)

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Smoothed particle hydrodynamics with smoothed pseudo-density [PDF]

open access: yesPublications of the Astronomical Society of Japan, 2015
Abstract In this paper, we present a new formulation of smoothed particle hydrodynamics (SPH), which, unlike the standard SPH (SSPH), is well behaved at the contact discontinuity. The SSPH scheme cannot handle discontinuities in density (e.g., the contact discontinuity and the free surface), because it requires that the density of fluid ...
Yamamoto, Satoko   +2 more
openaire   +2 more sources

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

open access: yesFEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani   +7 more
wiley   +1 more source

Cosmological constraints from noisy convergence maps through deep learning

open access: yes, 2018
Deep learning is a powerful analysis technique that has recently been proposed as a method to constrain cosmological parameters from weak lensing mass maps.
Amara, Adam   +5 more
core   +1 more source

MortalitySmooth: An R Package for Smoothing Poisson Counts with P-Splines

open access: yesJournal of Statistical Software, 2012
The MortalitySmooth package provides a framework for smoothing count data in both one- and two-dimensional settings. Although general in its purposes, the package is specifically tailored to demographers, actuaries, epidemiologists, and geneticists who ...
Carlo G. Camarda
doaj  

Improved Confidence Intervals for Expectiles

open access: yesMathematics
Expectiles were introduced to statistics around 40 years ago, but have recently gained renewed interest due to their relevance in financial risk management.
Spiridon Penev, Yoshihiko Maesono
doaj   +1 more source

Smooth and F--smooth systems

open access: yes, 2020
We review the geometric theory of \emp{smooth systems of smooth maps}, of \emp{smooth systems of smooth sections} of a smooth double fibred manifold and of \emp{smooth systems of smooth connections} of a smooth fibred manifold. Moreover, after reviewing the concept of \emp{F-smooth space} due to A.
Janyška, Josef, Modugno, Marco
openaire   +2 more sources

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

open access: yesFEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman   +4 more
wiley   +1 more source

Smoothing and Differentiation of Kinematic Data Using Functional Data Analysis Approach: An Application of Automatic and Subjective Methods

open access: yesApplied Sciences, 2020
Smoothing is one of the fundamental procedures in functional data analysis (FDA). The smoothing parameter λ influences data smoothness and fitting, which is governed by selecting automatic methods, namely, cross-validation (CV) and generalized ...
Muhammad Athif Mat Zin   +3 more
doaj   +1 more source

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