Results 71 to 80 of about 1,946,431 (327)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
INFORMATION MODELING AND SYSTEM DYNAMICS INTERPRETATION OF CONVENTIONAL ENGINES
Advanced Engineering Research, 2010 An original improvement of modern information models of conventional engine is proposed. Within the model all internal as well as external processes related to engine are integrated to a general system.
Evgeny N. LADOSHA +2 more
doaj
On Smoothing and the Bootstrap
The Annals of Statistics, 1989 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Hall, Peter +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
ARBTools: A Tricubic Spline Interpolator for Three-Dimensional Scalar or Vector Fields
Journal of Open Research Software, 2019 ARBTools is a Python library containing a Lekien-Marsden type tricubic spline method for interpolating three-dimensional scalar or vector fields presented as a set of discrete data points on a regular cuboid grid.
Paul Walker, Ulrich Krohn, David Carty
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Optimal bandwidth selection for recursive Gumbel kernel density estimators
Dependence Modeling, 2019 In this paper, we propose a data driven bandwidth selection of the recursive Gumbel kernel estimators of a probability density function based on a stochastic approximation algorithm.
Slaoui Yousri
doaj +1 more source
CollocInfer: Collocation Inference in Differential Equation Models
Journal of Statistical Software, 2016 This monograph details the implementation and use of the CollocInfer package in R for smoothing-based estimation of continuous-time nonlinear dynamic systems.
Giles Hooker, James O. Ramsay, Luo Xiao
doaj +1 more source
Journal of Knot Theory and Its Ramifications, 2012 We construct two knot invariants. The first knot invariant is a matrix constructed using linking numbers. This matrix can be represented as a two variable polynomial. The second is an invariant of flat knots and is a formal sum of flat knots obtained by smoothing pairs of crossings. This invariant can be used in conjunction with other flat invariants,
openaire +3 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source